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Antimicrobial Antioxidant Activities and HPLC Determination of the Major Components of Verbena carolina (Verbenaceae)

机译：马鞭草（马鞭草科）主要成分的抗菌抗氧化活性和HPLC测定

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摘要

Verbena carolina L. (Verbenaceae) is used as a decoction in Mexican folk medicine with applications against digestive problems and for dermatological infections. The present work firstly reported HPLC analysis, as well as the free radical scavenging capacity of the extracts and isolated compounds. Antimicrobial analyses of these substances against the bacteria Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Salmonella typhi and the fungi Candida albicans, Trichophyton mentagrophytes and T. rubrum were also tested, as well as the acute oral toxicity in mice of aqueous extracts. Major secondary metabolites in V. carolina extracts were isolated by conventional phytochemical methods which consisted of three terpenoids ((1), (3) and (4)) and four phenolic compounds ((2), (4)–(6)). Their contents were determined by HPLC in six different samples from different locations. The results indicated that ursolic acid (1), hispidulin (2), verbenaline (3), hastatoside (4), verbascoside (5), hispidulin 7-O-β-d-glucuronopyranoside (6) and pectolinaringenin-7-O-α-d-glucuronopyranoside (7) were the main constituents and ranged from 0.17 to 3.37 mg/g of dried plant, with verbascoside being the most abundant and with a significant antioxidant activity in reactive oxygen species (ROS). Hispidulin was the only active compound against T. mentagrophytes and T. rubrum. The aqueous extract showed no significant toxicity (LD50: > 5000 mg/mL). To our knowledge, this is the first comprehensive report of the chemical characterization of V. carolina and also of the activity of its constituents towards reactive oxygen species and dermatophytes, and its safety for consumption.
机译：马鞭草（Verbenaaceae）在墨西哥民间医学中用作汤剂，可用于抵抗消化系统疾病和皮肤病感染。本工作首先报道了HPLC分析，以及提取物和分离的化合物的自由基清除能力。还测试了这些物质对金黄色葡萄球菌，粪肠球菌，大肠杆菌和伤寒沙门氏菌以及白色念珠菌，门氏癣菌和风疹衣原体的抗菌分析，以及水提取物对小鼠的急性口服毒性。通过常规植物化学方法分离了卡罗莱纳州烟草提取物中的主要次要代谢产物，该方法由三种萜类化合物（（1），（3）和（4））和四种酚类化合物（（2），（4）-（6））组成。通过HPLC在不同位置的六个不同样品中测定了它们的含量。结果表明，熊果酸（1），组织蛋白（2），马鞭草碱（3），哈司他苷（4），马鞭草苷（5），组织蛋白7-O-β-d-葡萄糖醛酸吡喃糖苷（6）和果胶苷2-7-O- α-d-葡萄糖醛酸吡喃糖苷（7）是主要成分，干燥植物的含量在0.17至3.37 mg / g之间，其中马鞭草糖苷含量最高，并且在活性氧（ROS）中具有显着的抗氧化活性。 Hispidulin是唯一的抗棉铃虫和风铃虫的活性化合物。水提取物无明显毒性（LD50：> 5000 mg / mL）。据我们所知，这是关于卡罗莱纳州烟草的化学特性及其成分对活性氧和皮肤癣菌的活性及其食用安全性的第一份综合报告。

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