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首页> 美国卫生研究院文献>Molecules >A Comparative Study on the Effects of Different Parts of Panax ginseng on the Immune Activity of Cyclophosphamide-Induced Immunosuppressed Mice
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A Comparative Study on the Effects of Different Parts of Panax ginseng on the Immune Activity of Cyclophosphamide-Induced Immunosuppressed Mice

机译：人参不同部位对环磷酰胺诱导的免疫抑制小鼠免疫活性影响的比较研究

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The objective of the present study was to compare the effects of the immunological activity of various parts (root/stem/leaf/flower/seed) of five-year-old ginseng on the immune system of immunosuppressive mice. Immunosuppression was induced by cyclophosphamide (CTX) in the mouse model, whereas levamisole hydrochloride tablet (LTH) was used for the positive control group. We found that ginseng root (GRT), ginseng leaf (GLF), and ginseng flower (GFR) could relieve immunosuppression by increased viability of NK cells, enhanced immune organ index, improved cell-mediated immune response, increased content of CD4+ and ratio of CD4+/CD8+, and recovery of macrophage function, including carbon clearance, phagocytic rate, and phagocytic index, in immunodeficient mice. However, ginseng stem (GSM) and ginseng seed (GSD) could only enhance the thymus indices, carbon clearance, splenocyte proliferation, NK cell activities, and the level of IL-4 in immunosuppressed mice. In CTX-injected mice, GRT and GFR remarkably increased the protein expression of Nrf2, HO-1, NQO1, SOD1, SOD2, and CAT in the spleen. As expected, oral administration of GRT and GFR markedly enhanced the production of cytokines, such as IL-1β, IL-4, IL-6, IFN-γ, and TNF-α, compared with the CTX-induced immunosuppressed mice, and GRT and GFR did this relatively better than GSM, GLF, and GSD. This study provides a theoretical basis for further study on different parts of ginseng.
机译：本研究的目的是比较五岁人参各部分（根/茎/叶/花/种子）的免疫活性对免疫抑制小鼠免疫系统的影响。在小鼠模型中，免疫抑制是由环磷酰胺（CTX）诱导的，而盐酸左旋咪唑片（LTH）被用作阳性对照组。我们发现人参根（GRT），人参叶（GLF）和人参花（GFR）可以通过增加NK细胞的活力，增强免疫器官指数，改善细胞介导的免疫反应，增加CD4含量来减轻免疫抑制作用免疫缺陷小鼠的+ 和CD4 + / CD8 + 比例，以及巨噬细胞功能的恢复，包括碳清除率，吞噬率和吞噬指数。但是，人参茎（GSM）和人参种子（GSD）只能增强免疫抑制小鼠的胸腺指数，碳清除率，脾细胞增殖，NK细胞活性以及IL-4的水平。在注射CTX的小鼠中，GRT和GFR显着增加了脾脏中Nrf2，HO-1，NQO1，SOD1，SOD2和CAT的蛋白质表达。如预期的那样，与CTX诱导的免疫抑制小鼠和GRT相比，口服GRT和GFR显着增强了细胞因子的生成，例如IL-1β，IL-4，IL-6，IFN-γ和TNF-α。而GFR在这方面比GSM，GLF和GSD更好。本研究为人参不同部位的进一步研究提供了理论依据。

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