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Novel Anti-Aging Benzoquinone Derivatives from Onosma bracteatum Wall

机译：洋葱小os的新型抗衰老苯醌衍生物

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摘要

The aim of this study was to investigate anti-aging molecules from Onosma bracteatum Wall, a traditional medicinal plant used in the Unani and Ayurvedic systems of medicine. During bioassay-guided isolation, two known benzoquinones, allomicrophyllone (>1) and ehretiquinone (>2) along with three novel benzoquinones designated as ehretiquinones B–D (>3−>5) were isolated from O. bracteatum. Their structures were characterized by spectroscopic analysis through 1D and 2D NMR, by MS spectroscopic analysis and comparing with those reported in the literatures. The anti-aging potential of the isolated benzoquinones was evaluated through a yeast lifespan assay, and the results indicated that >1, >2, >4 and >5 significantly extended the replicative lifespan of K6001 yeast, indicating that these benzoquinones obtained from O. brateatum have the ability to be employed as a potential therapeutic agent against age-related diseases.
机译：这项研究的目的是研究Onosma bracteatum Wall（一种用于Unani和Ayurvedic医药系统的传统药用植物）的抗衰老分子。在生物测定指导的分离过程中，两个已知的苯醌，异种微动植物酮（> 1 ）和ehretiquinone（> 2 ）以及三个被称为ehretiquinones B–D（> 3 < / strong>-> 5 ）是从啤酒糖中分离出来的。它们的结构通过1D和2D NMR的光谱分析，MS光谱分析并与文献报道的结构进行比较。通过酵母寿命测定法评估了分离出的苯醌的抗衰老潜力，结果表明> 1 ，> 2 ，> 4 和< strong> 5 显着延长了K6001酵母的复制寿命，这表明从甜菜根中获得的这些苯醌具有用作抗衰老相关疾病的潜在治疗剂的能力。

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