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Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells

机译：伊马替尼通过抑制RGC-5视网膜神经节细胞中的PDGF-而非胰岛素诱导的PI 3-激酶/ Akt生存信号转导诱导凋亡

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PurposePlatelet-derived growth factor (PDGF) and insulin promote the survival of neuronal cells, including retinal ganglion cells (RGCs), via activation of phosphoinositide 3-kinase (PI 3-kinase)/Akt signaling. Of importance, recent studies have shown that imatinib inhibition of PDGF receptors induces retinal toxicity in some patients. To date, the extent of activation and the functional significance of insulin-induced PI 3-kinase/Akt signaling remain unclear in the context of dysregulated PDGF receptor signaling in retinal cells. In the present study, we tested the hypothesis that the pro-survival effect of insulin-induced PI 3-kinase/Akt signaling is compromised by imatinib inhibition of PDGF receptor signaling in RGCs.

机译：目的血小板源性生长因子（PDGF）和胰岛素通过激活磷酸肌醇3-激酶（PI 3-kinase）/ Akt信号传导来促进神经元细胞（包括视网膜神经节细胞（RGC））的存活。重要的是，最近的研究表明，伊马替尼抑制PDGF受体会在某些患者中引起视网膜毒性。迄今为止，在视网膜细胞中PDGF受体信号转导失调的情况下，胰岛素诱导的PI 3激酶/ Akt信号转导的活化程度和功能意义尚不清楚。在本研究中，我们测试了以下假设这一假设：胰岛素诱导的PI 3-激酶/ Akt信号传导的促生存作用受到伊马替尼抑制RGC中PDGF受体信号传导的损害。

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期刊名称 Molecular Vision
作者
Swarajit K. Biswas; Yan Zhao; Lakshman Sandirasegarane;
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年(卷),期 2009(15),-1
年度 2009
页码 1599–1610
总页数 12
原文格式 PDF
正文语种
中图分类分子生物学;眼科学;
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专利

1. Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells [J] . Biswas Swarajit K., Sandirasegarane Lakshman, Zhao Yan Molecular vision . 2009,第2009期

机译：伊马替尼通过抑制RGC-5视网膜神经节细胞中的PDGF-而非胰岛素诱导的PI 3-激酶/ Akt生存信号转导诱导凋亡
2. Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells [J] . Swarajit K. BiswasYan ZhaoLakshman Sandirasegarane Molecular vision . 2009,第2009期

机译：伊马替尼通过抑制RGC-5视网膜神经节细胞中的PDGF-而非胰岛素诱导的PI 3-激酶/ Akt生存信号转导诱导凋亡
3. Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells [J] . Swarajit K. BiswasYan ZhaoLakshman Sandirasegarane Molecular vision . 2009,第2009期

机译：伊马替尼通过抑制RGC-5视网膜神经节细胞中的PDGF-而非胰岛素诱导的PI 3-激酶/ Akt生存信号转导诱导凋亡
4. PI 3-kinase, Akt/PKB and Ras signalling pathways involved in the control of cell survival [C] . Julian Downward NATO Advanced Study Institute on Molecular Mechanisms of Signal Transduction . 2000

机译：PI 3-激酶，AKT / PKB和RAS信号传导途径涉及细胞存活的控制
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Bauerane Induces S-Phase Cell Cycle Arrest Apoptosis and Inhibition of Proliferation of A549 Human Lung Cancer Cells Through the Phosphoinositide 3-Kinase (PI3K)/AKT and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway [O] . Qin Chen, Ming Wang, Chengji Shen 2020

机译：Bauerane通过磷酸肌醇3-激酶（PI3K）/ AKT以及信号转导和转录激活因子3（STAT3）信号通路诱导S期细胞周期阻滞凋亡和A549人肺癌细胞增殖的抑制。
7. PDGF- and Insulin/IGF-1–Specific Distinct Modes of Class I A PI 3-Kinase Activation in Normal Rat Retinas and RGC-5 Retinal Ganglion Cells [O] . Swarajit K. Biswas, Yan Zhao, Arumugam Nagalingam, 2013

机译：pDGF-和胰岛素/ IGF-1特异性I类差异模式正常大鼠视网膜和RGC-5视网膜神经节细胞中pI3-激酶活化

Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells

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