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Nanoparticle-Mediated Therapeutic Agent Delivery for Treating Metastatic Breast Cancer—Challenges and Opportunities

机译：纳米粒子介导的治疗性转移药物治疗转移性乳腺癌的挑战与机遇

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Breast cancer (BC) is the second leading cause of cancer-related death in American women and more than 90% of BC-related death is caused by metastatic BC (MBC). This review stresses the limited success of traditional therapies as well as the use of nanomedicine for treating MBC. Understanding the biological barriers of MBC that nanoparticle in vivo trafficking must overcome could provide valuable new insights for translating nanomedicine from the bench side to the bedside. A view about nanomedicine applied in BC therapy has been summarized with their present status, which is gaining attention in the clinically-applied landscape. The progressions of drug/gene delivery systems, especially the status of their preclinical or clinical trials, are also discussed. Here we highlight that the treatment of metastasis, in addition to the extensively described inhibition of primary tumor growth, is an indispensable requirement for nanomedicine. Along with more innovations in material chemistry and more progressions in biology, nanomedicine will constantly supply more exciting new approaches for targeted drug/gene delivery against MBC.
机译：乳腺癌（BC）是美国女性癌症相关死亡的第二大主要原因，而BC相关死亡的90％以上是由转移性BC（MBC）引起的。这篇综述强调了传统疗法的有限成功，以及使用纳米药物治疗MBC。了解纳米颗粒体内运输必须克服的MBC的生物障碍，可以为将纳米医学从实验台转化为床侧提供有价值的新见解。总结了有关纳米药物在BC治疗中的应用及其现状，这一观点在临床应用领域日益受到关注。还讨论了药物/基因递送系统的进展，特别是其临床前或临床试验的状态。在这里，我们强调指出，除了广泛描述的对原发肿瘤生长的抑制作用之外，转移的治疗是纳米医学必不可少的要求。随着材料化学方面的更多创新和生物学方面的更多进步，纳米医学将不断提供针对MBC的靶向药物/基因递送的更令人兴奋的新方法。

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