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首页> 美国卫生研究院文献>NeuroImage : Clinical >Fixel-based analysis of the preterm brain: Disentangling bundle-specific white matter microstructural and macrostructural changes in relation to clinical risk factors
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Fixel-based analysis of the preterm brain: Disentangling bundle-specific white matter microstructural and macrostructural changes in relation to clinical risk factors

机译：基于Fixel的早产儿大脑分析：解开束特异性白质的微观结构和宏观结构变化与临床危险因素的关系

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Diffusion MRI (dMRI) studies using the tensor model have identified abnormal white matter development associated with perinatal risk factors in preterm infants studied at term equivalent age (TEA). However, this model is an oversimplification of the underlying neuroanatomy. Fixel-based analysis (FBA) is a novel quantitative framework, which identifies microstructural and macrostructural changes in individual fibre populations within voxels containing crossing fibres. The aim of this study was to apply FBA to investigate the relationship between fixel-based measures of apparent fibre density (FD), fibre bundle cross-section (FC), and fibre density and cross-section (FDC) and perinatal risk factors in preterm infants at TEA. We studied 50 infants (28 male) born at 24.0–32.9 (median 30.4) weeks gestational age (GA) and imaged at 38.6–47.1 (median 42.1) weeks postmenstrual age (PMA). dMRI data were acquired in non-collinear directions with b-value 2500 s/mm2 on a 3 Tesla system sited on the neonatal intensive care unit. FBA was performed to assess the relationship between FD, FC, FDC and PMA at scan, GA at birth, days on mechanical ventilation, days on total parenteral nutrition (TPN), birthweight z-score, and sex. FBA reveals fibre population-specific alterations in FD, FC and FDC associated with clinical risk factors. FD was positively correlated with GA at birth and was negatively correlated with number of days requiring ventilation. FC was positively correlated with GA at birth, birthweight z-scores and was higher in males. FC was negatively correlated with number of days on ventilation and days on TPN. FDC was positively correlated with GA at birth and birthweight z-scores, negatively correlated with days on ventilation and days on TPN and higher in males. We demonstrate that these relationships are fibre-specific even within regions of crossing fibres. These results show that aberrant white matter development involves both microstructural changes and macrostructural alterations.
机译：使用张量模型的扩散MRI（dMRI）研究已经确定了在足月等效年龄（TEA）研究的早产儿中与围产期危险因素相关的异常白质发育。但是，此模型过于简化了潜在的神经解剖结构。基于Fixel的分析（FBA）是一种新颖的定量框架，可识别包含交叉纤维的体素内单个纤维种群的微观结构和宏观结构变化。这项研究的目的是应用FBA来研究基于固定装置的表观纤维密度（FD），纤维束横截面（FC），纤维密度和横截面（FDC）与围产期危险因素之间的关系。 TEA的早产儿。我们研究了50名婴儿（28名男性），它们在胎龄（GA）的24.0-32.9（中位数30.4）周时出生，在月经后（PMA）的38.6-47.1（中位数42.1）周时成像。 dMRI数据是在新生儿重症监护病房的3 Tesla系统上沿非共线方向以b值2500 s / mm 2 采集的。进行FBA是为了评估扫描时FD，FC，FDC和PMA，出生时GA，机械通气天数，总肠胃外营养（TPN）天数，出生体重z评分和性别之间的关系。 FBA揭示了与临床危险因素相关的FD，FC和FDC中纤维群特异性改变。出生时FD与GA呈正相关，与需要通气的天数呈负相关。 FC与出生时的GA，出生体重的Z得分呈正相关，而在男性中则更高。 FC与通气天数和TPN天数呈负相关。 FDC与出生时GA和出生体重z分数呈正相关，与通气天数和TPN天数呈负相关，男性较高。我们证明，即使在交叉纤维的区域内，这些关系也是特定于纤维的。这些结果表明异常的白质发展涉及微观结构变化和宏观结构改变。

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