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Decreased calcineurin immunoreactivity in the postmortem brain of a patient with schizophrenia who had been prescribed the calcineurin inhibitor tacrolimus for leukemia

机译：精神分裂症患者的死后大脑中钙调神经磷酸酶的免疫反应性降低该患者已开具了钙调神经磷酸酶抑制剂他克莫司用于治疗白血病

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BackgroundThe calcineurin (CaN) inhibitor, tacrolimus, is widely used in patients undergoing allogeneic organ transplantation and in those with certain allergic diseases. Recently, several reports have suggested that CaN is also associated with schizophrenia. However, little data are currently available on the direct effect of tacrolimus on the human brain.

机译：背景钙调神经磷酸酶（CaN）抑制剂他克莫司广泛用于接受同种异体器官移植的患者以及患有某些过敏性疾病的患者。最近，一些报道表明CaN也与精神分裂症有关。但是，目前尚无有关他克莫司对人脑的直接作用的数据。

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期刊名称 Neuropsychiatric Disease and Treatment
作者
Akira Wada; Yasuto Kunii; Jyunya Matsumoto; Mizuki Hino; Atsuko Nagaoka; Shin-ichi Niwa; Hirooki Yabe;
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作者单位

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年(卷),期 2016(12),-1
年度 2016
页码 1645–1650
总页数 6
原文格式 PDF
正文语种
中图分类神经病学;精神病学;
关键词
calcineurin calcineurin inhibitors schizophrenia postmortem brain immunohistochemistry;

机译：钙调神经磷酸酶;钙调神经磷酸酶抑制剂;精神分裂症;死后脑;免疫组化;

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1. Decreased calcineurin immunoreactivity in the postmortem brain of a patient with schizophrenia who had been prescribed the calcineurin inhibitor, tacrolimus, for leukemia [J] . Akira Wada, Yasuto Kunii, Jyunya Matsumoto, Neuropsychiatric Disease and Treatment . 2016,第1期

机译：精神分裂症患者的死后脑中钙调神经磷酸酶免疫反应性降低，该患者已开具钙调神经磷酸酶抑制剂他克莫司用于白血病
2. Postmortem brain calcineurin protein levels in schizophrenia patients are not different from controls. [J] . Kozlovsky N, Scarr E, Dean B, Schizophrenia research . 2006,第2a3期

机译：精神分裂症患者的死后脑钙调神经磷酸蛋白水平与对照组无差异。
3. CLINICAL OUTCOME IN HEART TRANSPLANT RECIPIENTS (HTX) RECEIVING EVEROLIMUS IN COMBINATION WITH THE CALCINEURIN INHIBITOR TACROLIMUS OR CYCLOSPORIN A IN COMPARISON WITH A CALCINEURIN INHIBITOR FREE IMMUNOSUPPRESSIVE THERAPY [J] . Fuchs U., Zittermann A., Meschede E., Transplant international : . 2016,第Suppla3期

机译：钙转运蛋白抑制剂和钙环蛋白A联合钙转运蛋白抑制剂和游离钙免疫抑制剂联合接受依维莫司治疗的人心脏移植受体（HTX）的临床结果
4. UTILIZATION OF AN EMR-BIOREPOSITORY TO IDENTIFY THE GENETIC PREDICTORS OF CALCINEURIN-INHIBITOR TOXICITY IN HEART TRANSPLANT RECIPIENTS [C] . MATTHEW OETJENS, WILLIAM S. BUSH, KELLY A. BIRDWELL, Pacific Symposium on Biocomputing . 2014

机译：利用EMR-BioRepository以鉴定心脏移植受者钙素抑制剂毒性的遗传预测因子
5. Pharmacokinetics of intraarterial calcineurin inhibitor delivery to composite tissue: A study of regional and systemic advantages of intraarterial delivery of calcineurin inhibitors (cyclosporine and tacrolimus) to a vascularly isolated rabbit forelimb. [D] . Shirbacheh, Mansour V. 1999

机译：动脉钙调神经磷酸酶抑制剂向复合组织递送的药代动力学：钙调神经磷酸酶抑制剂（环孢素和他克莫司）向血管分离的兔前肢的动脉内递送的区域和全身优势的研究。
6. The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus [O] . Sharareh Siamakpour-Reihani, Joseph Caster, Desh Bandhu Nepal, 2008

机译：钙调神经磷酸酶/ NFAT在SFRP2诱导的血管生成中的作用—用钙调神经磷酸酶抑制剂他克莫司治疗乳腺癌的基本原理
7. The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus [O] . Siamakpour-Reihani, Sharareh, Caster, Joseph, Bandhu Nepal, Desh, 2011

机译：钙调神经磷酸酶/ NFAT在SFRP2诱导的血管生成中的作用—用钙调神经磷酸酶抑制剂他克莫司治疗乳腺癌的基本原理

Decreased calcineurin immunoreactivity in the postmortem brain of a patient with schizophrenia who had been prescribed the calcineurin inhibitor tacrolimus for leukemia

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