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首页> 美国卫生研究院文献>The Neuroradiology Journal >A voxel-based morphometric magnetic resonance imaging study of the brain detects age-related gray matter volume changes in healthy subjects of 21–45 years old
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A voxel-based morphometric magnetic resonance imaging study of the brain detects age-related gray matter volume changes in healthy subjects of 21–45 years old

机译：基于体素的大脑形态计量磁共振成像研究检测了21-45岁健康受试者中与年龄相关的灰质体积变化

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Previous and more recent work of analyzing structural changes in the brain suggest that certain brain regions such as the frontal lobe are among the brain regions profoundly affected by the aging process across males and females. Also, a unified model of structural changes in a normally aging brain is still lacking. The present study investigated age-related structural brain changes in gray matter from young to early middle-age adulthood for males and females. Magnetic resonance images of 215 normal and healthy participants between the ages of 21–45 years were acquired. Changes in gray matter were assessed using voxel-based morphometry and gray matter volumetric analysis. The results showed significant decrease in gray matter volume between the youngest and oldest groups in the following brain regions: frontal, temporal, and parietal lobes. Grey matter loss in the frontal lobe was among the most widespread of all brain regions across the comparison groups that showed significant age-related changes in grey matter for both males and females. This work provides a unique pattern of age-related decline of normal and healthy adult males and females that can aid in the future development of a unified model of normal brain aging.
机译：先前和最近进行的分析大脑结构变化的研究表明，某些大脑区域（例如额叶）是受男性和女性衰老过程影响深刻的大脑区域。而且，仍然缺乏在正常衰老的大脑中结构变化的统一模型。本研究调查了从年龄到成年成年男性和女性的年龄相关的大脑灰质结构变化。获得了21至45岁之间的215名正常和健康参与者的磁共振图像。使用基于体素的形态计量学和灰质体积分析来评估灰质的变化。结果显示，在以下大脑区域（额叶，颞叶和顶叶）中，最年轻和最老的组之间的灰质体积显着减少。在比较组中，额叶灰质的丢失是所有大脑区域中分布最广泛的，在男性和女性中，灰质的变化都与年龄有关。这项工作提供了正常和健康的成年男性和女性与年龄相关的衰老的独特模式，可以帮助将来发展正常大脑衰老的统一模型。

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