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Computation of statistical secondary structure of nucleic acids.

机译:核酸统计二级结构的计算。

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摘要

This paper presents a computer analysis of statistical secondary structure of nucleic acids. For a given single stranded nucleic acid, we generated "structure map" which included all the annealing structures in the sequence. The map was transformed into "energy map" by rough approximation; here, the energy level of every pairing structure consisting of more than 2 successive nucleic acid pairs was calculated. By using the "energy map", the probability of occurrence of each annealed structure was computed, i.e., the structure was computed statistically. The basis of computation was the 8-queen problem in the chess game. The validity of our computer programme was checked by computing tRNA structure which has been well established. Successful application of this programme to small nuclear RNAs of various origins is demonstrated.
机译:本文介绍了核酸统计二级结构的计算机分析。对于给定的单链核酸,我们生成了“结构图”,其中包括序列中的所有退火结构。通过粗略近似将地图转换为“能源地图”。在此,计算了由两个以上连续核酸对组成的每个配对结构的能级。通过使用“能量图”,计算出每种退火结构的出现概率,即,统计地计算该结构。计算的基础是象棋游戏中的8皇后问题。我们的计算机程序的有效性通过计算已经确定的tRNA结构进行了检查。证明了该程序成功应用于各种来源的小核RNA。

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