首页> 美国卫生研究院文献>Journal of Virology >Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus.
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Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus.

机译:脾脏聚焦形成病毒的Friend毒株:小鼠C型嗜温病毒序列与异种病毒相关序列之间的重组体。

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摘要

The genome of the Friend strain of the spleen focus-forming virus (SFFV) has been analyzed by molecular hybridization. SFFV is composed of genetic sequences homologous to Friend type C helper virus (F-MuLV) and SFFV-specific sequences not present in F-MuLV. These SFFV-specific sequences are present in both the Friend and Rauscher strains of murine erythroleukemia virus. The SFFV-specific sequences are partially homologous to three separate strains of mouse xenotropic virus but not to several cloned mouse ecotropic viruses. Thus, the Friend strain of SFFV appears to be a recombinant between a portion of the F-MuLV genome and RNA sequences that are highly related to murine xenotropic viruses. The implications of the acquisition of the xenotropic virus-related sequences are discussed in relation to the leukemogenicity of SFFV, and a model for the pathogenicity of other murine leukemia-inducing viruses is proposed.
机译:脾脏聚焦形成病毒(SFFV)的Friend菌株的基因组已通过分子杂交进行了分析。 SFFV由与Friend C型辅助病毒(F-MuLV)同源的基因序列和F-MuLV中不存在的SFFV特异性序列组成。这些SFFV特异性序列在鼠红白血病病毒的Friend和Rauscher菌株中均存在。 SFFV特异性序列与小鼠异种病毒的三个单独的毒株部分同源,但与几种克隆的小鼠嗜性病毒没有部分同源性。因此,SFFV的Friend株似乎是F-MuLV基因组的一部分与与鼠类异种病毒高度相关的RNA序列之间的重组体。讨论了与异种病毒相关序列的获取的意义,与SFFV的致白血病性相关,并提出了其他鼠类白血病诱导病毒的致病性模型。

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