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首页> 外文期刊>Journal of Virology >Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus.
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Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus.

机译：脾脏聚焦成对病毒的朋友菌株：小鼠型C型生态病毒病毒序列和与异熵病毒相关的序列之间的重组。

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The genome of the Friend strain of the spleen focus-forming virus (SFFV) has been analyzed by molecular hybridization. SFFV is composed of genetic sequences homologous to Friend type C helper virus (F-MuLV) and SFFV-specific sequences not present in F-MuLV. These SFFV-specific sequences are present in both the Friend and Rauscher strains of murine erythroleukemia virus. The SFFV-specific sequences are partially homologous to three separate strains of mouse xenotropic virus but not to several cloned mouse ecotropic viruses. Thus, the Friend strain of SFFV appears to be a recombinant between a portion of the F-MuLV genome and RNA sequences that are highly related to murine xenotropic viruses. The implications of the acquisition of the xenotropic virus-related sequences are discussed in relation to the leukemogenicity of SFFV, and a model for the pathogenicity of other murine leukemia-inducing viruses is proposed.
机译：通过分子杂交分析了脾脏聚焦成型病毒（SFFV）的朋友菌株的基因组。 SFFV由与朋友型C辅助病毒（F-MULV）同源的遗传序列组成，以及F-MULV中不存在的SFFV特异性序列。这些SFFV特异性序列存在于鼠红细胞苏达血症病毒的朋友和Rauscher菌株中。 SFFV特异性序列与三种单独的小鼠异孔病毒的三种单独的菌株是局部同源的，但不是几种克隆的小鼠生态疾病病毒。因此，SFFV的朋友菌株似乎是与鼠异熵病毒高度相关的F-Mulv基因组和RNA序列之间的重组。关于SFFV的白血病性讨论了对异胞病毒相关序列的影响，提出了用于其他鼠白血病诱导病毒的致病性的模型。

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