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首页> 美国卫生研究院文献>Nutrients >Postprandial Effect of a High-Fat Meal on Endotoxemia in Arab Women with and without Insulin-Resistance-Related Diseases
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Postprandial Effect of a High-Fat Meal on Endotoxemia in Arab Women with and without Insulin-Resistance-Related Diseases

机译：餐后高脂餐对阿拉伯妇女患有和不患有胰岛素抵抗相关疾病的内毒素血症的影响

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This study determined the effects of a high-fat meal on circulating endotoxin and cardiometabolic indices in adult Arab women. The cohort consisted of 92 consenting Saudi women (18 non-diabetic (ND)) control subjects; Age 24.4 ± 7.9 year; body mass index (BMI) 22.2 ± 2.2 Kg/m2), 24 overweight/obese (referred to as overweight-plus (overweight+)) subjects (Age 32.0 ± 7.8 year; BMI 28.5 ± 1.5 Kg/m2) and 50 type 2 diabetes mellitus (T2DM) patients (Age 41.5 ± 6.2 year; BMI 35.2 ± 7.7 Kg/m2). All were given a high-fat meal (standardized meal: 75 g fat, 5 g carbohydrate, 6 g protein) after an overnight fast of 12–14 h. Anthropometrics were obtained and fasting blood glucose, lipids, and endotoxin were serially measured for four consecutive postprandial hours. Endotoxin levels were significantly elevated prior to a high-fat meal in the overweight+ and T2DM than the controls (p < 0.05). Furthermore, the postprandial cardiometabolic changes led to a more detrimental risk profile in T2DM subjects than other groups, with serial changes most notable in glucose, triglycerides, high density lipoprotein-cholesterol (HDL-cholesterol), and insulin levels (p-values < 0.05). The same single meal given to subjects with different metabolic states had varying impacts on cardiometabolic health. Endotoxemia is exacerbated by a high-fat meal in Arab subjects with T2DM, accompanied by a parallel increase in cardiometabolic risk profile, suggesting disparity in disease pathogenesis of those with or without T2DM through the altered cardiometabolic risk profile rather than variance in metabolic endotoxinaemia with a high-fat meal.
机译：这项研究确定了高脂膳食对成年阿拉伯妇女循环内毒素和心脏代谢指标的影响。该队列由92名同意接受沙特妇女（18名非糖尿病（ND））对照受试者组成；年龄24.4±7.9岁;体重指数（BMI）22.2±2.2 Kg / m 2 ），24名超重/肥胖（称为超重加（overweight + ））受试者（年龄32.0± 7.8年； BMI 28.5±1.5 Kg / m 2 ）和50例2型糖尿病（T2DM）患者（年龄41.5±6.2年； BMI 35.2±7.7 Kg / m 2 ）。在通宵禁食12至14小时后，所有人都吃了高脂餐（标准餐：75 g脂肪，5 g碳水化合物，6 g蛋白）。获得人体测量学，并连续四个餐后连续测量空腹血糖，脂质和内毒素。高脂餐前，超重 + 和T2DM中的内毒素水平显着高于对照组（p <0.05）。此外，餐后心脏代谢变化导致T2DM受试者的危险性比其他组更高，其系列变化最明显的是葡萄糖，甘油三酸酯，高密度脂蛋白胆固醇（HDL-胆固醇）和胰岛素水平（p值<0.05） ）。给予具有不同代谢状态的受试者相同的一顿饭对心脏代谢健康有不同的影响。高脂饮食在患有T2DM的阿拉伯受试者中加剧了内毒素血症，并伴随着心脏代谢风险特征的同时增加，这表明通过改变心脏代谢风险特征而不是通过代谢性内毒素血症的变异，患有或不患有T2DM的患者的发病机制存在差异高脂餐。

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