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Unexpected Perinatal Loss versus Sids-a Common Neuropathologic Entity

机译:意外的围产期丢失与Sids-常见的神经病理学实体

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摘要

Objective: To evaluate the involvement of alterations of the central autonomic nervous system, particularly of the brainstem and cerebellum, in a wide set of victims of sudden and unexplained perinatal and infant death. Material and Methods: The study population consisted of 63 stillbirths, 28 neonatal deaths and 140 suspected SIDS. The victims were subjected to in-depth anatomopathological examination following appropriate guidelines. The protocol included, in particular, the histological evaluation on serial sections of the cardiorespiratory autonomic nervous system. Results: A diagnosis of “unexplained death” was established for 217 of the 231 victims (59 stillbirths, 28 newborns and 130 SIDS). In a very high percentage of these deaths (84%) we observed one or more anomalies of the nuclei and/or structures of the brainstem and cerebellum related to vital functions. Conclusion: Unexpected perinatal loss should not be regarded as a separate entity from SIDS, given the common neuropathological substrates.
机译:目的:评估中枢自主神经系统的变化,尤其是脑干和小脑的变化,是否涉及围产期和婴儿猝死的原因不明的婴儿。材料和方法:研究人群包括63个死产,28个新生儿死亡和140个可疑小岛屿发展中国家。按照适当的指导原则对受害者进行了深入的解剖病理学检查。该方案特别包括对心肺自主神经系统连续切片的组织学评估。结果:231名受害者中有217名(死产59名,28名新生儿和130名SIDS)被诊断为“无法解释的死亡”。在这些死亡的极高百分比(84%)中,我们观察到与生命功能相关的一个或多个核和/或脑干和小脑结构异常。结论:考虑到常见的神经病理学底物,不应将意外的围产期损失与SIDS分开考虑。

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