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首页> 外文期刊>Virchows Archiv >Guidelines for neuropathologic diagnostics of perinatal unexpected loss and sudden infant death syndrome (SIDS)—a technical protocol
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Guidelines for neuropathologic diagnostics of perinatal unexpected loss and sudden infant death syndrome (SIDS)—a technical protocol

机译：围产期意外丢失和婴儿猝死综合症（SIDS）的神经病理学诊断指南-技术规程

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摘要

In light of the growing information on the pathophysiology and clinical aspects of unexpected perinatal loss and sudden infant death syndrome (SIDS), a novel approach to the inherent problems by pathologists has become necessary. Herein, we propose an up-to-date protocol for accurate examination of the central autonomic nervous system and of the cardiac conduction system, which can encompass morphological and/or functional abnormalities of reliable epicritical value in unexplained perinatal loss and SIDS, particularly in those cases (still quite numerous) lacking adequate clinical documentation. Anatomo-pathologic examination of the central autonomic nervous system includes an in-depth study on histological serial sections of the brainstem, cerebellum, and spinal cord, where the main structures participating in control of the vital functions are located. For the histological study of the cardiac conductions system, serial sections were obtained from two blocks, including the sino-atrial node and the atrio-ventricular system, respectively. This type of updated investigation is yielding important arguments for a broader discussion of the pathogenesis of unexpected stillbirth, early neonatal death, and SIDS, besides allowing a more complete forensic-medical documentation of individual cases.
机译：鉴于关于意外的围产期丧失和婴儿猝死综合症（SIDS）的病理生理学和临床方面的信息越来越多，病理学家需要一种新颖的方法来解决固有问题。本文中，我们提出了用于精确检查中枢自主神经系统和心脏传导系统的最新协议，该协议可以涵盖在无法解释的围产期丢失和SIDS中（尤其是在那些无法解释的围产期丢失和SIDS中）具有可靠的上位临界值的形态和/或功能异常病例（仍然很多）缺乏足够的临床文献。中枢植物神经系统的解剖病理学检查包括对脑干，小脑和脊髓的组织学连续切片的深入研究，在这些组织中，参与控制生命功能的主要结构位于其中。为了进行心脏传导系统的组织学研究，分别从两个模块（包括窦房结和房室系统）获得了连续切片。这种类型的更新调查为重要的死因，意想不到的死产，早期新生儿死亡和SIDS的发病机理的广泛讨论提供了重要的论据，此外还允许对个案进行更完整的法医医学记录。

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