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Standardised Neuropsychological Assessment for the Selection of Patients Undergoing DBS for Parkinsons Disease

机译：选择帕金森病接受DBS的患者的标准化神经心理学评估

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DBS is an increasingly offered advanced treatment for Parkinson's disease (PD). Neuropsychological assessment is considered to be an important part of the screening for selection of candidates for this treatment. However, no standardised screening procedure currently exists. In this study, we examined the use of our standardised neuropsychological assessment for the evaluation of surgical candidates and to identify risk factors for subsequent decline in cognition and mood. A total of 40 patients were assessed before and after DBS. Evaluation of mood and case notes review was also undertaken. Before DBS, patients with PD demonstrated frequent impairments in intellectual functioning, memory, attention, and executive function, as well as high rates of mood disorder. Post-DBS, there was a general decline in verbal fluency only, and in one patient, we documented an immediate and irreversible global cognitive decline, which was associated with older age and more encompassing cognitive deficits at baseline. Case note review revealed that a high proportion of patients developed mood disorder, which was associated with higher levels of depression at baseline and greater reduction in levodopa medication. We conclude that our neuropsychological assessment is suitable for the screening of candidates and can identify baseline risk factors, which requires careful consideration before and after surgery.
机译：DBS是帕金森氏病（PD）越来越多的先进治疗方法。神经心理学评估被认为是筛选该治疗候选药物的重要组成部分。但是，目前不存在标准化的筛选程序。在这项研究中，我们检查了使用标准化神经心理学评估方法评估手术候选人并确定随后认知和情绪下降的危险因素。在DBS之前和之后总共评估了40名患者。还进行了情绪评估和病例笔记审查。在使用DBS之前，PD患者表现出频繁的智力功能，记忆力，注意力和执行功能障碍，并且情绪障碍发生率很高。 DBS后，仅语言流利性普遍下降，并且在一名患者中，我们记录了立即且不可逆的总体认知能力下降，这与年龄较大和基线时的认知功能障碍有关。病例笔记审查显示，很大比例的患者发展为情绪障碍，这与基线时抑郁水平更高和左旋多巴药物的减少程度更大有关。我们得出的结论是，我们的神经心理学评估适合筛选候选人，并且可以识别基线危险因素，这需要在手术前后进行仔细考虑。

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