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首页> 美国卫生研究院文献>Pharmaceutical Biology >Mechanistic assessment of the analgesic anti-inflammatory and antipyretic actions of Dalbergia saxatilis in animal models
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Mechanistic assessment of the analgesic anti-inflammatory and antipyretic actions of Dalbergia saxatilis in animal models

机译：机械化黄檀在动物模型中的止痛消炎和解热作用的机械评估

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>Context: Aqueous root extract of Dalbergia saxatilis, Hook, f., (Leguminosae) (DS) is reported useful for toothache, pains, and fever, but not scientifically proven.>Objective: This study determined its effectiveness in pain, inflammation, and fever, applying scientific models.>Materials and methods: Swiss mice or Sprague–Dawley rats (n = 5) were pretreated with distilled water, DS (100 or 200 mg/kg), or standard drug for 30 min. The analgesic activity was measured by acetic acid writhing, tail flick, tail immersion, tail clip, hot plate, and formalin pain tests; anti-inflammatory effects were determined via carrageenan and dextran rat paw oedema tests; antipyretic activity was measured by Escherichia coli lipopolysaccharide (ECL) and turpentine in rabbits, and d-amphetamine sulphate (d-AS) pyrexia test in rats.>Results: Writhing frequency inhibition was produced by 200 mg/kg DS (33.10%), aspirin (38.19%) and morphine (93.68%). Unlike morphine, DS did not produce significant prolongation of the reaction times in the hot-plate, tail immersion, tail flick, and tail clip tests. In the first and second phases of formalin test, respectively, % inhibition was: 200 mg/kg DS (25.70% and 0%), aspirin (4.76% and 67.33%), morphine (81.42% and 66.11%); for carrageenan and dextran tests, significant difference was recorded between 200 mg/kg DS and control up to 6 h. Significant reduction in ECL, turpentine and d-AS pyrexia was recorded at 100 and 200 mg/kg DS.>Conclusion: DS produces mild non-steroidal analgesic and anti-inflammatory, as well as significant antipyretic actions involving cyclooxygenase, α2 adrenoceptor and interleukin-1 β1 due to any of glycosides, saponins or phenolic tannins.
机译：>上下文：据报道，黄檀（Hook，f。）（豆科）（DS）的水根提取物可用于牙痛，疼痛和发烧，但未经科学证明。>目的：本研究使用科学模型确定了其在疼痛，炎症和发烧中的有效性。>材料和方法：瑞士小鼠或Sprague–Dawley大鼠（n = 5）用蒸馏水DS（ 100或200 mg / kg）或标准药物30 min。通过乙酸扭体，甩尾，浸入尾巴，尾夹，热板和福尔马林止痛试验来测量镇痛活性。通过角叉菜胶和葡聚糖大鼠爪水肿试验确定抗炎作用；用大肠埃希菌脂多糖（ECL）和松节油测定解热活性，并用d-苯异丙胺硫酸盐（d-AS）发热试验对大鼠进行解热。>结果： 200 mg / kg产生了抑制旋转频率的作用DS（33.10％），阿司匹林（38.19％）和吗啡（93.68％）。与吗啡不同，DS在热板，尾部浸入，尾部甩动和尾夹测试中并未显着延长反应时间。在福尔马林测试的第一和第二阶段，抑制百分率分别为：200μmg/ kg DS（25.70％和0％），阿司匹林（4.76％和67.33％），吗啡（81.42％和66.11％）；对于角叉菜胶和右旋糖酐测试，在200μg/ kg DS与控制至6μh的对照之间记录到明显差异。在100和200μmg/ kg DS下记录到ECL，松节油和d-AS发热明显降低。>结论： DS产生轻度的非甾体镇痛和抗炎作用，以及明显的退热作用，包括糖苷，皂苷或酚类单宁酸中的任何一种，导致环氧合酶，α2肾上腺素能受体和白介素-1β1升高。

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