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首页> 美国卫生研究院文献>Physiology and Molecular Biology of Plants >Phytochemicals of Salacia oblonga responsible for free radical scavenging and antiproliferative activity against breast cancer cell lines (MDA-MB-231)
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Phytochemicals of Salacia oblonga responsible for free radical scavenging and antiproliferative activity against breast cancer cell lines (MDA-MB-231)

机译：Salacia longlonga的植物化学物质负责自由基清除和抗乳腺癌细胞系的增殖活性（MDA-MB-231）

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Salacia oblonga, an inhabitant of tropical regions has been used in traditional Indian medicinal systems. Phytochemicals were extracted in methanol from the plant and analyzed for various biological activities. The results of biochemical tests for total phenolics (297 ± 0.005 and 275 ± 0.006) and flavonoids (95 ± 0.004 and 61.6 ± 0.004) in the aerial and root parts were indicated as Gallic acid and quercetin equivalents respectively. The Aerial and root extracts showed strong reducing ability based on reducing power and FRAP assays. The extracts exhibited significant IC50 values in DPPH, super oxide and nitric oxide radical scavenging assays. The extracts displayed low IC50 values (<50 μg/ml) when assessed for antiproliferative activity against breast cancer cell lines using the MTT assay. GC-MS analysis of methanolic extracts have revealed the presence of compounds viz. n-Hexadecanoic acid, N-Methoxy-N-methylacetamide, Ursa-9(11), 12-dien-3-ol, Gamma-sitosterol etc., that might be potential candidates for the biological activity exhibited by the extract.Electronic supplementary materialThe online version of this article (doi:10.1007/s12298-015-0317-z) contains supplementary material, which is available to authorized users.
机译：Salacia longlonga是热带地区的居民，已在传统的印度药用系统中使用。从植物的甲醇中提取植物化学物质，并分析其各种生物活性。地上部分和根部的总酚类（297±0.005和275±0.006）和类黄酮（95±0.004和61.6±0.004）的生化测试结果分别表示为没食子酸和槲皮素当量。根据还原能力和FRAP分析，气生和根提取物显示出强大的还原能力。提取物在DPPH，超氧化物和一氧化氮自由基清除试验中显示出显着的IC50值。使用MTT分析法评估提取物对乳腺癌细胞系的抗增殖活性时，提取物显示出低的IC50值（<50μg/ ml）。甲醇提取物的GC-MS分析表明存在化合物，即。正十六烷酸，N-甲氧基-N-甲基乙酰胺，Ursa-9（11），12-二烯-3-醇，γ-谷甾醇等可能是提取物具有生物活性的潜在候选物。材料本文的在线版本（doi：10.1007 / s12298-015-0317-z）包含补充材料，授权用户可以使用。

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