• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Journal of Virology >Neutralizing Anti-F Glycoprotein and Anti-Substance P Antibody Treatment Effectively Reduces Infection and Inflammation Associated with Respiratory Syncytial Virus Infection
【2h】

Neutralizing Anti-F Glycoprotein and Anti-Substance P Antibody Treatment Effectively Reduces Infection and Inflammation Associated with Respiratory Syncytial Virus Infection

机译：中和抗F糖蛋白和抗P物质抗体治疗可有效减少与呼吸道合胞病毒感染相关的感染和炎症

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Respiratory syncytial virus (RSV) is the most important virus mediating lower respiratory tract illness in infants and young children. RSV infection is associated with pulmonary inflammation and increased levels of substance P (SP), making the airways and leukocytes that express SP receptors susceptible to the proinflammatory effects of this peptide. This study examines combining neutralizing anti-F glycoprotein and anti-SP antibody treatment of RSV-infected BALB/c mice to inhibit RSV replication and inflammation associated with infection. BALB/c mice were prophylactically treated with antibody prior to RSV infection or were therapeutically treated at day 2 or 6 post-RSV infection. Prophylactic or therapeutic treatment with anti-SP antibodies promptly reduced pulmonary inflammatory cell infiltration and decreased the number of cells expressing proinflammatory cytokines, while anti-F antibody treatment reduced virus titers. The results suggest that combined anti-viral and anti-SP antibody treatment may be effective in treating RSV disease.
机译：呼吸道合胞病毒（RSV）是介导婴幼儿下呼吸道疾病的最重要病毒。 RSV感染与肺部炎症和P物质（SP）水平升高有关，使表达SP受体的气道和白细胞易受该肽的促炎作用。这项研究检查了结合中和的抗F糖蛋白和抗SP抗体治疗RSV感染的BALB / c小鼠，以抑制RSV复制和与感染相关的炎症。在RSV感染之前对BALB / c小鼠进行抗体预防性治疗，或者在RSV感染后第2天或第6天对BALB / c小鼠进行治疗。用抗SP抗体进行的预防性或治疗性治疗可迅速减少肺部炎症细胞浸润并减少表达促炎性细胞因子的细胞数量，而抗F抗体治疗则可降低病毒滴度。结果表明，抗病毒和抗SP抗体联合治疗可能有效治疗RSV疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号