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Thermoresponsive Hydrogels and Their Biomedical Applications: Special Insight into Their Applications in Textile Based Transdermal Therapy

机译：热敏性水凝胶及其生物医学应用：在基于纺织品的透皮治疗中的应用的特殊见解

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摘要

Various natural and synthetic polymers are capable of showing thermoresponsive properties and their hydrogels are finding a wide range of biomedical applications including drug delivery, tissue engineering and wound healing. Thermoresponsive hydrogels use temperature as external stimulus to show sol-gel transition and most of the thermoresponsive polymers can form hydrogels around body temperature. The availability of natural thermoresponsive polymers and multiple preparation methods of synthetic polymers, simple preparation method and high functionality of thermoresponsive hydrogels offer many advantages for developing drug delivery systems based on thermoresponsive hydrogels. In textile field applications of thermoresponsive hydrogels, textile based transdermal therapy is currently being applied using drug loaded thermoresponsive hydrogels. The current review focuses on the preparation, physico-chemical properties and various biomedical applications of thermoresponsive hydrogels based on natural and synthetic polymers and especially, their applications in developing functionalized textiles for transdermal therapies. Finally, future prospects of dual responsive (pH/temperature) hydrogels made by these polymers for textile based transdermal treatments are mentioned in this review.
机译：各种天然和合成聚合物都能够显示出热响应特性，并且它们的水凝胶正在发现广泛的生物医学应用，包括药物输送，组织工程和伤口愈合。热敏性水凝胶使用温度作为外部刺激来显示溶胶-凝胶转变，大多数热敏性聚合物可以在体温附近形成水凝胶。天然热响应性聚合物的可用性和合成聚合物的多种制备方法，热响应性水凝胶的简单制备方法和高功能性为开发基于热响应性水凝胶的药物递送系统提供了许多优势。在热响应性水凝胶在纺织领域的应用中，目前正在使用载有药物的热响应性水凝胶来进行基于纺织品的透皮治疗。目前的评论集中在基于天然和合成聚合物的热敏性水凝胶的制备，理化性质和各种生物医学应用，尤其是它们在开发用于经皮治疗的功能性纺织品中的应用。最后，在这篇评论中提到了由这些聚合物制成的双响应（pH /温度）水凝胶在基于纺织品的透皮治疗中的未来前景。

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