Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum Gallium Indium and Thallium

机译：无机IIIa类金属盐（铝镓铟和T的盐）的抗肿瘤活性和毒性

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The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose)50 as a measure, the decreasing order of toxicity was TlCl3 ≥ In(NO3)3 > Ga(NO3)3 > Al(NO3)3. All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga⁺³ and, to a lesser extent, In⁺³ inhibited tumor growth. Ga(NO3)3 was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man.

机译：测定了IIIa族金属铝，镓，铟和al的盐的毒性和抗肿瘤活性。以（致死剂量）50作为衡量标准，毒性降低的顺序为TlCl3≥In（NO3）3> Ga（NO3）3> Al（NO3）3。四种金属均显示出抗肿瘤活性，但是当以不同于药物的途径接种肿瘤时，只有Ga ^{+3 ，在较小程度上是In ^{+3 抑制肿瘤生长。发现Ga（NO3）3抑制了四分之三的啮齿动物实体瘤的生长。因此，镓对于治疗人体实体瘤具有潜在的治疗作用。}}

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期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
Michael M. Hart; Richard H. Adamson;
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年(卷),期 1971(68),7
年度 1971
页码 1623–1626
总页数 4
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7. Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium [O] . Hart, Michael M., Adamson, Richard H. 1971

机译：无机IIIa类金属盐（铝，镓，铟和T的盐）的抗肿瘤活性和毒性
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机译：部分Iiaia金属 - 金属氧化物体系的汽化 - 铟镓氧化物（Ga O和Ga O 2中）和氧化铝镓（Ga al O）的质谱鉴定

Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum Gallium Indium and Thallium

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