Monoclonal antibodies against rabies virus produced by somatic cell hybridization: detection of antigenic variants.

机译：通过体细胞杂交产生的抗狂犬病病毒的单克隆抗体：检测抗原变体。

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Somatic cell hybrids (hybridomas) between mouse myeloma cells and spleen cells derived from BALB/c mice immunized with inactivated rabies vaccine were found to produce antibodies to rabies virus. Monoclonal antibodies with different specificities were obtained either from the mass culture directly after fusion or from clones derived from a single-cell cloning procedure. Several strains of fixed or street rabies virus were analyzed by virus neutralization procedures which demonstrated differences in their antigenic composition. Hybridoma antibodies were able to protect experimental animals from lethal rabies virus infection.

机译：发现用灭活的狂犬病疫苗免疫的小鼠骨髓瘤细胞和源自BALB / c小鼠的脾细胞之间的体细胞杂种（杂交瘤）可产生针对狂犬病病毒的抗体。从融合后直接进行的大规模培养或从单细胞克隆程序获得的克隆中获得具有不同特异性的单克隆抗体。通过病毒中和程序分析了几种固定的或街头狂犬病毒株，证明了它们的抗原组成不同。杂交瘤抗体能够保护实验动物免于致命的狂犬病毒感染。

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期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
T J Wiktor; H Koprowski;
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年(卷),期 1978(75),8
年度 1978
页码 3938–3942
总页数 5
原文格式 PDF
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专利

1. Structural difference recognized by a monoclonal antibody #404-11 between the rabies virus nucleocapsid (NC) produced in virus infected cells and the NC-like structures produced in the nucleoprotein (N) cDNA-transfected cells. [J] . Toriumi H, Kawai A Microbiology and Immunology . 2005,第8期

机译：在病毒感染的细胞中产生的狂犬病毒核衣壳（NC）与在核蛋白（N）cDNA转染的细胞中产生的NC样结构之间，单克隆抗体＃404-11识别出结构差异。
2. Development of Monoclonal Antibodies Suitable for Rabies Virus Antibody and Antigen Detection [J] . Vishal Chander, R. P. Singh, P. C. Verma Indian Journal of Virology . 2012,第3期

机译：适用于狂犬病病毒抗体和抗原检测的单克隆抗体的开发
3. Development of Monoclonal Antibodies Suitable for Rabies Virus Antibody and Antigen Detection [J] . Vishal Chander, R. P. Singh, P. C. Verma Indian Journal of Virology . 2012,第3期

机译：适用于狂犬病病毒抗体和抗原检测的单克隆抗体的开发
4. WEIYSSA: a Simple Tool using Mouse Monoclonal Antibodies for the Detection of Lyssavirus Nucleocapsid in Rabies Suspected Specimens [C] . G. Xu, P. Weber, Q. Hu, Joint World Organisation for Animal Health/World Health Organization/European Union International Conference "Towards the elimination of rabies in Eurasia" . 2008

机译：Weiyssa：一种使用小鼠单克隆抗体检测狂犬病疑似标本的Lyssavirus Nuclecapsid的简单工具
5. Targeted delivery of antigens to follicular dendritic cells via a monoclonal antibody specific for complement receptor 2 on marginal zone B cells: Dynamics of delivery and applications towards vaccine development. [D] . Whipple, Emily Christine. 2006

机译：通过对边缘B区细胞的补体受体2特异的单克隆抗体，将抗原靶向递送至滤泡树突状细胞：动力学和疫苗开发应用。
6. Development of Monoclonal Antibodies Suitable for Rabies Virus Antibody and Antigen Detection [O] . Vishal Chander, R. P. Singh, P. C. Verma 2012

机译：适用于狂犬病病毒抗体和抗原检测的单克隆抗体的开发
7. Monoclonal antibodies against rabies virus produced by somatic cell hybridization: detection of antigenic variants. [O] . Wiktor, T J, Koprowski, H 1978

机译：通过体细胞杂交产生的针对狂犬病病毒的单克隆抗体：抗原变体的检测。
8. Antigen Detection with Monoclonal Antibodies for the Diagnosis of Adenovirus Gastroenteritis [R] . Herrmann, J. E. , Perron-Henry, D. M. , Blacklow, N. R. 1987

机译：用单克隆抗体检测抗原检测腺病毒性胃肠炎

Monoclonal antibodies against rabies virus produced by somatic cell hybridization: detection of antigenic variants.

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