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首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >Acquisition and loss of a neuronal Ca2+/calmodulin-dependent protein kinase during neuronal differentiation.
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Acquisition and loss of a neuronal Ca2+/calmodulin-dependent protein kinase during neuronal differentiation.

机译：神经元分化过程中神经元Ca2 + /钙调蛋白依赖性蛋白激酶的获得和丢失。

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摘要

Calcium ions play a critical role in neural development. Insights into the ontogeny of Ca(2+)-signaling pathways were gained by investigating the developmental expression of granule cell-enriched Ca2+/calmodulin-dependent protein kinase (CaM kinase-Gr) in the cerebellum and hippocampus of the rat. Neurons of these brain regions displayed characteristic schedules by which they acquired and lost CaM kinase-Gr during differentiation. In the cerebellum, granule cells did not begin to express CaM kinase-Gr until after birth when they migrated into the granule cell layer, and this expression persisted in the adult. Purkinje cells expressed CaM kinase-Gr prenatally and lost this expression by postnatal day 14. In contrast, the granule and pyramidal cells of the hippocampus expressed the enzyme prenatally and in the adult. Moreover, CaM kinase-Gr was localized to the processes and nuclei of developing neurons. This subcellular localization together with the scheduled expression of CaM kinase-Gr can serve to regulate a developing neuron's sensitivity to Ca2+ at different subcellular levels.
机译：钙离子在神经发育中起关键作用。通过研究大鼠小脑和海马中富含颗粒细胞的Ca2 + /钙调蛋白依赖性蛋白激酶（CaM激酶-Gr）的发育表达，可以了解Ca（2+）信号通路的存在。这些大脑区域的神经元显示出特征性的时间表，通过它们它们在分化过程中获得并丢失了CaM激酶-Gr。在小脑中，直到出生后颗粒细胞才迁移到颗粒细胞层，才开始表达CaM激酶-Gr，这种表达在成年后一直持续。浦肯野细胞在出生前表达CaM激酶-Gr，并在出生后第14天失去该表达。相反，海马的颗粒细胞和锥体细胞在产前和成人中表达该酶。此外，CaM激酶-Gr定位于发育中的神经元的过程和细胞核。这种亚细胞定位以及CaM激酶-Gr的预定表达可以在不同的亚细胞水​​平上调节发育中的神经元对Ca2 +的敏感性。

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