Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq

机译：缺乏Gαq的小鼠小脑浦肯野细胞运动协调障碍和持续性多攀神经支配

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摘要

Mice lacking the α-subunit of the heterotrimeric guanine nucleotide binding protein Gq (Gαq) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of the cerebellum is not overtly disturbed, and excitatory synaptic transmission from parallel fibers to cerebellar Purkinje cells (PCs) and from climbing fibers (CFs) to PCs is functional. However, about 40% of adult Gαq mutant PCs remain multiply innervated by CFs because of a defect in regression of supernumerary CFs in the third postnatal week. Evidence is provided suggesting that Gαq is part of a signaling pathway that is involved in the elimination of multiple CF innervation during this period.

机译：缺乏异三聚体鸟嘌呤核苷酸结合蛋白Gq（Gαq）的α亚基的小鼠是可行的，但患有运动障碍的典型运动障碍。小脑的解剖结构没有受到明显干扰，从平行纤维到小脑浦肯野细胞（PC）以及从攀爬纤维（CF）到PC的兴奋性突触传递是正常的。然而，由于产后第三周多余的CFs退化的缺陷，约40％的成年Gαq突变型PC仍被CFs支配。提供的证据表明，Gαq是信号传导途径的一部分，在此期间涉及消除多个CF的神经支配。

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期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
Stefan Offermanns; Kouichi Hashimoto; Masahiko Watanabe; William Sun; Hideo Kurihara; Richard F. Thompson; Yoshiro Inoue; Masanobu Kano; Melvin I. Simon;
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年(卷),期 1997(94),25
年度 1997
页码 14089–14094
总页数 6
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1. Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq [J] . Stefan Offermanns, Kouichi Hashimoto, Masahiko Watanabe Proceedings of the National Academy of Sciences of the United States of America . 1997,第25期

机译：缺乏Gαq的小鼠小脑浦肯野细胞运动协调障碍和持续性多发攀爬纤维神经支配
2. Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2. [J] . Ichikawa R, Miyazaki T, Kano M, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2002,第19期

机译：缺乏谷氨酸受体δ2的小脑浦肯野细胞中邻近棘突小节的异常布线导致攀登纤维区域的远端扩展和多支神经支配。
3. Impaired motor learning in the vestibulo-ocular reflex in mice with multiple climbing fiber input to cerebellar Purkinje cells. [J] . Kimpo RR, Raymond JL The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2007,第21期

机译：在向小脑浦肯野细胞输入多个攀登纤维的小鼠中，前庭眼反射的运动学习受损。
4. In Search Of Cerebellar Climbing Fiber Purkinje Cell Twins [C] . Dunin-Barkowski, W.L., Khandozhko, . 2001

机译：寻找小脑攀登纤维浦肯野双胞胎
5. Differential time course of loss of guinea pig cerebellar Purkinje cells and hippocampal CA1 pyramidal cells produced by chronic prenatal ethanol exposure and the role of apoptosis. [D] . McGoey, Tara Nadine. 2001

机译：豚鼠小脑浦肯野细胞和海马CA1锥体细胞的丢失在不同时间过程中所产生的慢性产前乙醇暴露和凋亡的作用。
6. Distal Extension of Climbing Fiber Territory and Multiple Innervation Caused by Aberrant Wiring to Adjacent Spiny Branchlets in Cerebellar Purkinje Cells Lacking Glutamate Receptor δ2 [O] . Ryoichi Ichikawa, Taisuke Miyazaki, Masanobu Kano, 2002

机译：缺乏谷氨酸受体δ2的小脑浦肯野细胞中相邻棘突小节的异常接线导致的攀登纤维区域的远端扩展和多神经支配。
7. Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galpha q [O] . Offermanns Stefan, Hashimoto Kouichi, Watanabe Masahiko, 1997

机译：缺乏Galpha q的小鼠小脑Purkinje细胞的运动协调能力受损和持续的多次攀爬纤维神经支配

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq

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