首页> 外国专利> TRANSGENIC NON-HUMAN MAMMAL THAT SPECIFICALLY EXCESSIVELY EXPRESSING TARGET GENE IN CEREBELLAR PURKINJE CELL, BRAIN STEM, OR OLFACTORY BULB IN BRAIN

TRANSGENIC NON-HUMAN MAMMAL THAT SPECIFICALLY EXCESSIVELY EXPRESSING TARGET GENE IN CEREBELLAR PURKINJE CELL, BRAIN STEM, OR OLFACTORY BULB IN BRAIN

机译：在人类小脑浦肯野细胞，脑干或嗅球中特异表达目标基因的转基因非人类哺乳动物

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摘要

PROBLEM TO BE SOLVED: To prepare a model animal of cerebellar purkinje cell-affecting disease.SOLUTION: There is provided a transgenic non-human mammal which is obtained by introducing a murine stem cell virus (MSCV) promoter and a vector including a target gene connected to the MSCV promoter in a germline, for specifically excessively expressing the target gene in a cerebellar purkinje cell, a cell brain stem or an olfactory bulb in a brain.

机译：解决的问题：制备小脑浦肯野细胞感染性疾病的模型动物。解决方案：提供了一种转基因非人类哺乳动物，其通过引入鼠干细胞病毒（MSCV）启动子和包含靶基因的载体获得连接至种系中的MSCV启动子，用于在小脑浦肯野细胞，细胞脑干或大脑中的嗅球中特异性过量表达目标基因。

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公开/公告号JP2011254701A

专利类型
公开/公告日2011-12-22

原文格式PDF
申请/专利权人 GUNMA UNIV;
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申请/专利号JP20100129021
发明设计人 HIRAI HIROKAZU;
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申请日2010-06-04
分类号A01K67/027;C12Q1/02;C12N15/09;C12N5/10;G01N33/15;G01N33/50;A61K31/7088;A61K48;A61K35/76;A61P43;A61P25;
国家 JP
入库时间 2022-08-21 17:39:38

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