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The maternal-effect selfish genetic element Medea is associated with a composite Tc1 transposon

机译:具有母性作用的自私遗传元素美狄亚与复合Tc1转座子相关

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摘要

Maternal-Effect Dominant Embryonic Arrest (“Medea”) factors are selfish nuclear elements that combine maternal-lethal and zygotic-rescue activities to gain a postzygotic survival advantage. We show that Medea1 activity in Tribolium castaneum is associated with a composite Tc1 transposon inserted just downstream of the neurotransmitter reuptake symporter bloated tubules (blot), whose Drosophila ortholog has both maternal and zygotic functions. The 21.5-kb insertion contains defective copies of elongation initiation factor-3, ATP synthase subunit C, and an RNaseD-related gene, as well as a potentially intact copy of a prokaryotic DUF1703 gene. Sequence comparisons suggest that the current distribution of Medea1 reflects global emanation after a single transpositional event in recent evolutionary time. The Medea system in Tribolium represents an unusual type of intragenomic conflict and could provide a useful vehicle for driving desirable genes into populations.
机译:母体效应优势胚胎逮捕(“ Medea”)因子是自私的核元素,结合了母体致命和合子拯救活动以获得合子后生存优势。我们显示,Tribolium castaneum中的Medea 1 活性与正好插入神经递质再摄取同向转运小管(印迹)下游的复合Tc1转座子相关,果蝇直向同源物既具有母体功能又具有合子功能。 21.5 kb的插入片段包含延伸起始因子3,ATP合酶亚基C和RNaseD相关基因的缺陷拷贝,以及原核DUF1703基因的潜在完整拷贝。序列比较表明,美狄亚 1 的当前分布反映了在最近的进化时间中发生一次易位事件后的整体散发。 Tribolium 中的Medea系统代表一种不常见的内部基因组冲突类型,可以为将所需基因驱动到群体中提供有用的载体。

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