• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >From the Cover: Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town South Africa
【2h】

From the Cover: Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town South Africa

机译：从封面：南非开普敦的维生素D状况和结核病通报的季节性相互变化

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Vitamin D deficiency is associated with susceptibility to tuberculosis (TB) in HIV-uninfected people in Europe, but it is not known whether such an association exists among HIV-infected people in subtropical Africa. We conducted a cross-sectional study to determine whether vitamin D deficiency was associated with susceptibility to active TB in HIV-uninfected (n = 196) and HIV-infected (n = 174) black Africans in Cape Town, South Africa. We also investigated whether there was evidence of seasonal variation in vitamin D status and TB notifications in this setting over an 8-y period. Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] <50 nmol/L) was present in 232 (62.7%) of 370 participants and was associated with active TB in both HIV-uninfected (odds ratio = 5.2, 95% confidence interval: 2.8–9.7; P < 0.001) and HIV-infected (odds ratio = 5.6, 95% confidence interval: 2.7–11.6; P < 0.001) people. Vitamin D status varied according to season: The mean serum 25(OH)D concentration was highest in January through March and lowest in July through September (56.8 vs. 30.7 nmol/L, respectively; P < 0.001). Reciprocal seasonal variation in TB notifications was observed: The mean number of TB notifications per quarter for Cape Town in 2003 to 2010 was lowest in April through June and highest in October through December (4,222 vs. 5,080; P < 0.001). Vitamin D deficiency is highly prevalent among black Africans in Cape Town and is associated with susceptibility to active TB both in the presence and absence of HIV infection. Reciprocal seasonal variation in serum 25(OH)D concentration and TB notifications suggests that seasonal variations in vitamin D status and TB incidence in this setting are causally related.
机译：维生素D缺乏症与欧洲未感染HIV的人群对结核病（TB）的易感性有关，但未知在亚热带非洲的HIV感染者中是否存在这种关联。我们进行了一项横断面研究，以确定在南非开普敦，未感染艾滋病毒的非洲黑人（n = 196）和感染了艾滋病毒的非洲黑人（n = 174）中维生素D缺乏与易感性结核的易感性是否相关。我们还调查了在这种情况下在8年内是否存在维生素D状况和结核病通报的季节性变化的证据。 370名参与者中的232名（62.7％）存在维生素D缺乏症（血清25-羟基维生素D [25（OH）D] <50 nmol / L），并且在未感染HIV的两名患者中均与活动性结核相关（比值= 5.2， 95％的置信区间：2.8–9.7； P <0.001）和感染了HIV的人（几率= 5.6，95％的置信区间：2.7–11.6； P <0.001）。维生素D的状态随季节而变化：血清25（OH）D的平均浓度在1月至3月最高，7月至9月最低（分别为56.8和30.7 nmol / L； P <0.001）。观察到的结核病通报有季节性的相互变化：2003年至2010年，开普敦每季度的结核病通报平均数在4月至6月最低，在10月至12月最高（4,222对5,080； P <0.001）。在开普敦的非洲黑人中，维生素D缺乏症非常普遍，并且在存在和不存在HIV感染的情况下，维生素D缺乏症都容易导致活动性结核病。血清25（OH）D浓度和结核病通报的季节性相互变化表明，这种情况下维生素D状况和结核病发病率的季节性变化具有因果关系。

著录项

相似文献

  • 外文文献
  • 中文文献
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号