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首页> 美国卫生研究院文献>Royal Society Open Science >Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers
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Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers

机译：聚（丙交酯-共-乙交酯）-（聚-L-鸟氨酸/岩藻依聚糖）核-壳纳米载体的主要生物相容性测试

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Layer-by-layer (LbL) self-assembly is the technology used in intermolecular static electricity, hydrogen bonds, covalent bonds and other polymer interactions during film assembling. This technology has been widely studied in the drug carrier field. Given their use in drug delivery systems, the biocompatibility of these potential compounds should be addressed. In this work, the primary biocompatibility of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) [PLGA-(PLO/fucoidan)] core–shell nanoparticles (NPs) was investigated. Atomic force microscopy revealed the PLGA-(PLO/Fucoidan)4 NPs to be spherical, with a uniform size distribution and a smooth surface, and the NPs were stable in physiological saline. The residual amount of methylene chloride was further determined by headspace gas chromatography, in which the organic solvent can be volatilized during preparation. Furthermore, cell viability, acridine orange/ethidium bromide staining, haemolysis and mouse systemic toxicity were all assessed to show that PLGA-(PLO/fucoidan)4 NPs were biocompatible with cells and mice. Therefore, these NPs are expected to have potential applications in future drug delivery systems.
机译：逐层（LbL）自组装是一种在膜组装过程中用于分子间静电，氢键，共价键和其他聚合物相互作用的技术。该技术已在药物载体领域得到广泛研究。考虑到它们在药物输送系统中的使用，应该解决这些潜在化合物的生物相容性。在这项工作中，研究了聚（丙交酯-共-乙交酯）-（聚-L-鸟氨酸/岩藻依聚糖）[PLGA-（PLO /岩藻依聚糖）]核-壳纳米粒子（NPs）的主要生物相容性。原子力显微镜显示PLGA-（PLO /岩藻依聚糖）4 NPs为球形，具有均匀的尺寸分布和光滑的表面，并且在生理盐水中稳定。通过顶空气相色谱法进一步确定二氯甲烷的残留量，其中有机溶剂可在制备过程中挥发。此外，对细胞活力，orange啶橙/溴化乙锭染色，溶血作用和小鼠全身毒性进行了评估，均显示PLGA-（PLO /岩藻依聚糖）4 NP与细胞和小鼠具有生物相容性。因此，预期这些NP在未来的药物递送系统中具有潜在的应用。

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