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Oxidative actions of hydrogen peroxide in human gingival and oral periosteal fibroblasts: Responses to glutathione and nicotine relevant to healing in a redox environment

机译：过氧化氢在人牙龈和口腔骨膜成纤维细胞中的氧化作用：对谷胱甘肽和尼古丁的反应与氧化还原环境下的愈合有关

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BackgroundThis study aims to validate pro-oxidant actions of nicotine (N), using hydrogen peroxide (H2O2) and the antioxidant glutathione (G) in an in vitro model of human gingival fibroblasts (HGF) and human oral periosteal fibroblasts (HPF); radiolabelled androgens are used as biomarkers of redox status. Oxidative stress is an important mediator of inflammatory repair. The androgen metabolite 5α-dihydrotestosterone (DHT) is an effective biomarker of oxidative stress and healing.

机译：背景本研究旨在在人牙龈成纤维细胞（HGF）和人口腔骨膜成纤维细胞（HPF）的体外模型中使用过氧化氢（H2O2）和抗氧化剂谷胱甘肽（G）来验证尼古丁（N）的促氧化作用;放射性标记的雄激素被用作氧化还原状态的生物标记。氧化应激是炎症修复的重要介质。雄激素代谢物5α-二氢睾丸激素（DHT）是氧化应激和愈合的有效生物标志物。

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期刊名称 Redox Biology
作者
Federico Tinti; Mena Soory;
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作者单位

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年(卷),期 2014(2),-1
年度 2014
页码 36–43
总页数 8
原文格式 PDF
正文语种
中图分类生物学;
关键词
Hydrogen peroxide Nicotine Glutathione Oxidative stress Redox markers Wound healing;

机译：过氧化氢;尼古丁;谷胱甘肽;氧化应激;氧化还原标记物;伤口愈合;

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专利

1. Oxidative actions of hydrogen peroxide in human gingival and oral periosteal fibroblasts: Responses to glutathione and nicotine, relevant to healing in a redox environment [J] . Federico Tinti, Mena Soory Redox Biology . 2014,第1期

机译：过氧化氢在人牙龈和口腔骨膜成纤维细胞中的氧化作用：对谷胱甘肽和尼古丁的反应，与氧化还原环境下的愈合有关
2. Anabolic Actions of the Regenerative Agent Enamel Matrix Derivative (EMD) in Oral Periosteal Fibroblasts and MG 63 Osteoblasts, Modulation by Nicotine and Glutathione in a Redox Environment [J] . Mena Soory, Tareq Al-Qattan Journal of Functional Biomaterials . 2012,第1期

机译：再生剂搪瓷基质衍生物（EMD）在口腔骨膜成纤维细胞和MG 63成骨细胞中的合成代谢作用，氧化还原环境中尼古丁和谷胱甘肽的调节
3. Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment [J] . Li Xiao, Nobuhiko Miwa Human cell: official journal of Human Cell Research Society . 2017,第2期

机译：富含氢水的含氢水分从培养物或3D-组织当量的人牙龈成纤维细胞中的氧化应激损伤，以及伤口愈合促进，以及来自谷胱甘肽的清除和浮雕
4. Surface reaction of titanium oxide film to fluoride and hydrogen peroxide in simulated oral environment [C] . Shinji Takemoto, Masayuki Hattori, Masao Yoshinari International Symposium on Ceramics in Medicline . 2009

机译：氧化钛膜对模拟口腔环境中氟化物和过氧化氢的表面反应
5. Antioxidant defense and redox responses to telomere homolog oligonucleotides in human dermal fibroblasts: A model for investigating redox signaling responses to DNA damage. [D] . Lee-Bellantoni, Margaret So He. 2005

机译：对人类皮肤成纤维细胞中端粒同源寡核苷酸的抗氧化防御和氧化还原反应：研究对DNA损伤的氧化还原信号反应的模型。
6. Anabolic Actions of the Regenerative Agent Enamel Matrix Derivative (EMD) in Oral Periosteal Fibroblasts and MG 63 Osteoblasts Modulation by Nicotine and Glutathione in a Redox Environment [O] . Tareq Al-Qattan, Mena Soory 2012

机译：再生剂搪瓷基质衍生物（EMD）在口腔骨膜成纤维细胞和MG 63成骨细胞中的合成代谢作用在氧化还原环境中尼古丁和谷胱甘肽的调节
7. Oxidative actions of hydrogen peroxide in human gingival and oral periosteal fibroblasts:responses to glutathione and nicotine relevant to healing in a redox environment [O] . Tinti, Federico, Soory, Menaka 2014

机译：过氧化氢在人牙龈和口腔骨膜成纤维细胞中的氧化作用：对氧化还原环境中与愈合有关的谷胱甘肽和尼古丁的反应

Oxidative actions of hydrogen peroxide in human gingival and oral periosteal fibroblasts: Responses to glutathione and nicotine relevant to healing in a redox environment

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