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首页> 美国卫生研究院文献>Renal Failure >Long-term renal and overall survival of critically ill patients with acute renal injury who received continuous renal replacement therapy
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Long-term renal and overall survival of critically ill patients with acute renal injury who received continuous renal replacement therapy

机译：接受连续性肾脏替代治疗的重症急性肾损伤患者的长期肾脏和总体生存率

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>Background: Acute kidney injury (AKI) is associated with the increased short-term mortality of critically ill patients on continuous renal replacement therapy (CRRT). The aim of this research was to evaluate the association of kidney function at discharge with the long-term renal and overall survival of critically ill patients with AKI who were on CRRT in an intensive care unit (ICU).>Methods: We retrospectively collected data for critically ill patients with AKI who were admitted to ICU on CRRT at a tertiary metropolitan hospital in China between 2008 and 2013. The patients were followed up to their death or to 30 September 2016 by telephone.>Results: A total of 403 patients were enrolled in this study. The 1-, 3- and 5-year patient survival rates were 64.3 ± 2.4, 55.8 ± 2.5 and 46.3 ± 2.7%, respectively. In multivariate analysis, age, sepsis, decreased renal perfusion (including volume contraction, congestive heart failure, hypotension and cardiac arrest), preexisting kidney disease, Apache II score, Saps II score, vasopressors and eGFR <45 mL/min/1.73 m2 at discharge were independent factors for worse long-term patient survival. And age, preexisting kidney disease, Apache II score, mechanical ventilation (MV) and eGFR <45 mL/min/1.73 m2 at discharge were also associated with worse renal survival.>Conclusions: This study showed that impaired kidney function at discharge was shown to be an important risk factor affecting the long-term renal survival rates of critically ill patients with AKI. An eGFR <45 mL/min/1.73 m2 was an independent risk factor for decreased overall survival and renal survival.
机译：>背景：急性肾脏损伤（AKI）与接受连续肾脏替代治疗（CRRT）的危重患者短期死亡率增加相关。这项研究的目的是评估重症监护病房（ICU）接受CRRT的重症AKI重症AKI患者的出院时肾脏功能与长期肾脏和整体生存的相关性。>方法：我们回顾性收集了2008年至2013年间在中国一家大城市医院接受CRRT入ICU的重症AKI患者的数据。对患者进行了随访，直至死亡或直到2016年9月30日为止。>结果：该研究共纳入403名患者。 1年，3年和5年患者生存率分别为64.3％±2.4％，55.8％±2.5％和46.3％±2.7％。在多变量分析中，年龄，败血症，肾脏灌注减少（包括体积收缩，充血性心力衰竭，低血压和心脏骤停），先前存在的肾脏疾病，Apache II评分，Saps II评分，升压药和eGFR <45 mL / min / 1.73 m <出院时sup> 2 是长期患者生存状况较差的独立因素。并且年龄，出院前的肾脏疾病，Apache II评分，机械通气（MV）和出院时eGFR <45 mL / min / 1.73 m 2 也与肾脏存活率下降有关。>结论：< / strong>该研究表明，出院时肾功能受损是影响AKI重症患者长期肾脏存活率的重要危险因素。 eGFR <45 mL / min / 1.73 m 2 是降低整体生存率和肾脏生存率的独立危险因素。

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