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Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors

机译：鼠白血病病毒诱导的晚期肿瘤中γ-逆转录病毒插入转录激活的新原理

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BackgroundInsertional mutagenesis screens of retrovirus-induced mouse tumors have proven valuable in human cancer research and for understanding adverse effects of retroviral-based gene therapies. In previous studies, the assignment of mouse genes to individual retroviral integration sites has been based on close proximity and expression patterns of annotated genes at target positions in the genome. We here employed next-generation RNA sequencing to map retroviral-mouse chimeric junctions genome-wide, and to identify local patterns of transcription activation in T-lymphomas induced by the murine leukemia gamma-retrovirus SL3-3. Moreover, to determine epigenetic integration preferences underlying long-range gene activation by retroviruses, the colocalization propensity with common epigenetic enhancer markers (H3K4Me1 and H3K27Ac) of 6,117 integrations derived from end-stage tumors of more than 2,000 mice was examined.

机译：背景技术逆转录病毒诱导的小鼠肿瘤的诱变筛选筛查已被证明对人类癌症研究和了解基于逆转录病毒的基因疗法的不良反应有价值。在以前的研究中，将小鼠基因分配给单个逆转录病毒整合位点的方法是基于注释基因在基因组目标位置的紧密接近和表达模式。在这里，我们采用了下一代RNA测序技术来在全基因组范围内绘制逆转录病毒-小鼠嵌合连接，并确定鼠白血病伽马逆转录病毒SL3-3诱导的T淋巴瘤中转录激活的局部模式。此外，为了确定通过逆转录病毒激活远距离基因的潜在表观遗传整合偏好，研究了与来自2000多只小鼠的晚期肿瘤的6,117例整合的常见表观遗传增强子标记（H3K4Me1和H3K27Ac）的共定位倾向。

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期刊名称 Retrovirology
作者
Martin Sokol; Matthias Wabl; Irene Rius Ruiz; Finn Skou Pedersen;
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作者单位

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年(卷),期 2014(11),-1
年度 2014
页码 36
总页数 20
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
Gamma-retrovirus Insertional mutagenesis Oncogenesis Deep sequencing Chromatin immunoprecipication with sequencing (ChIP-seq) Retroviral integration sites RNA sequencing (RNA-seq);

机译：γ-逆转录病毒;插入诱变;致癌作用;深度测序;染色质与测序的免疫沉淀（ChIP-seq）;逆转录病毒整合位点;RNA测序（RNA-seq）;

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专利

1. Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors [J] . Martin Sokol, Matthias Wabl, Irene Rius Ruiz, Retrovirology . 2014,第S1期

机译：鼠白血病病毒诱导的晚期肿瘤中γ-逆转录病毒插入转录激活的新原理
2. Moloney murine leukemia virus-induced myeloid tumors in adult BALB/c mice: requirement of c-myb activation but lack of v-abl involvement. [J] . G L Shen-Ong, L Wolff Journal of Virology . 1987,第12期

机译：Moloney鼠白血病病毒诱导成人BALB / C小鼠的骨髓肿瘤：C-MYB激活的要求，但缺乏V-ABL参与。
3. Moloney murine leukemia virus-induced myeloid tumors in adult BALB/c mice: requirement of c-myb activation but lack of v-abl involvement. [J] . G L Shen-Ong, L Wolff Journal of Virology . 1987,第12期

机译：Moloney鼠白血病病毒诱导成人BALB / C小鼠的骨髓肿瘤：C-MYB激活的要求，但缺乏V-ABL参与。
4. Anti-tumor effect of photochemical treatment by an optical parametric oscillator (OPO) laser with two photosensitizers administrations for trans-planted tumor of cultivated murine leukemia (L5178Y) [C] . Norio Miyoshi, Zhao-Hui Jin, Kazumori Ishiguro, Shanghai international conference on laser medicine and surgery . 1998

机译：光学参数振荡器（OPO）激光与培养鼠白血病栽培肿瘤的两种光敏振荡器（OPO）激光的抗肿瘤效应（OPO）激光（L5178Y）
5. The functional study of transcriptional corepressor G-protein supressor 2 (GPS2) and tumor supressor promyelocytic leukemia (PML). [D] . Cheng, Xiwen. 2010

机译：转录共抑制因子G蛋白抑制因子2（GPS2）和肿瘤抑制因子早幼粒细胞白血病（PML）的功能研究。
6. Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomas. [O] . S E Bear, A Bellacosa, P A Lazo, 2017

机译：Tpl-1（一种与Ets-1相关的癌基因）中的原病毒插入与莫洛尼鼠白血病病毒诱导的大鼠胸腺淋巴瘤中的肿瘤进展有关。
7. Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors [O] . Martin Sokol, Matthias Wabl, Irene Ruiz, 2014

机译：鼠白血病病毒诱导的晚期肿瘤中γ-逆转录病毒插入转录激活的新原理

Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors

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