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首页> 美国卫生研究院文献>Schizophrenia Bulletin >Temporal Stability and Moderating Effects of Age and Sex on CNTRaCS Task Performance
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Temporal Stability and Moderating Effects of Age and Sex on CNTRaCS Task Performance

机译：时间稳定性和年龄和性别对CNTRaCS任务绩效的调节作用

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Research in schizophrenia has increasingly focused on incorporating measures from cognitive neuroscience, but little is known about their psychometric characteristics. Here, we extend prior research by reporting on temporal stability, as well as age and sex effects, for cognitive neuroscience paradigms optimized as part of the Cognitive Neuroscience Test Reliability and Clinical applications for Schizophrenia consortium. Ninety-nine outpatients with schizophrenia and 131 healthy controls performed 5 tasks assessing 4 constructs at 3 sessions. The constructs were (1) Goal maintenance (Dot Probe Expectancy [DPX] and AX continuous performance tasks [AX-CPT]); (2) Episodic memory (Relational and Item-Specific Encoding and Retrieval task [RiSE]); (3) Visual integration (Jittered Orientation Visual Integration task [JOVI]); and (4) Perceptual gain control (Contrast-Contrast Effect Task [CCE]). Patients performed worse than controls on all but the CCE, and the magnitude of these group differences was stable across sessions, with no sex differences observed. Improvements over sessions were seen for the AX-CPT, the DPX, and the JOVI though practice effects for the AX-CPT and the DPX were primarily present in older participants. For the AX-CPT and the JOVI, practice effects were larger for T1 to T2 than for T2 to T3. Age was associated with poor associative recognition on the RiSE and accuracy on the JOVI. Test-rest reliability ranged from poor for the JOVI threshold score to adequate to good for the DPX, AX-CPT, and JOVI accuracy measures, with RiSE and CCE measures in the moderate range. These results suggest that group differences in DPX, AX-CPT, RiSE, and JOVI are robust and consistent across repeated testing.
机译：精神分裂症的研究越来越集中于结合认知神经科学的措施，但对其心理测量特征了解甚少。在这里，我们通过报告时间稳定性以及年龄和性别影响来扩展先前的研究，以优化作为精神分裂症联盟认知神经科学测试可靠性和临床应用的一部分而优化的认知神经科学范式。 99名精神分裂症门诊患者和131名健康对照者执行了5项任务，在3个疗程中评估了4种结构。构造是（1）目标维护（点探针期望[DPX]和AX连续执行任务[AX-CPT]）； （2）情景记忆（关系和项特定的编码和检索任务[RiSE]）； （3）视觉集成（抖动定向视觉集成任务[JOVI]）； （4）知觉增益控制（Contrast-Contrast Effect Task [CCE]）。除CCE以外，其他所有患者的表现均较对照组差，并且这些组间差异的大小在整个疗程中保持稳定，未观察到性别差异。尽管AX-CPT，DPX和JOVI的练习效果主要出现在年龄较大的参与者中，但在会话方面有所改善。对于AX-CPT和JOVI，T1至T2的练习效果比T2至T3的练习效果大。年龄与RiSE的不良关联识别和JOVI的准确性相关。测试休息可靠性的范围从JOVI阈值得分的差到DPX，AX-CPT和JOVI精度测量的足够到良好，而RiSE和CCE的测量值在中等范围。这些结果表明，在重复测试中，DPX，AX-CPT，RiSE和JOVI中的组差异是强大且一致的。

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