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Simultaneous Estimation of Hydrochlorothiazide Hydralazine Hydrochloride and Reserpine Using PCA NAS and NAS-PCA

机译:使用PCANAS和NAS-PCA同时估算氢氯噻嗪盐酸肼屈嗪和利血平

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摘要

In this study, new and feasible UV-visible spectrophotometric and multivariate spectrophotometric methods were described for the simultaneous determination of hydrochlorothiazide (HCTZ), hydralazine hydrochloride (H.HCl), and reserpine (RES) in combined pharmaceutical tablets. Methanol was used as a solvent for analysis and the whole UV region was scanned from 200–400 nm. The resolution was obtained by using multivariate methods such as the net analyte signal method (NAS), principal component analysis (PCA), and net analyte signal-principal component analysis (NAS-PCA) applied to the UV spectra of the mixture. The results obtained from all of the three methods were compared. NAS-PCA showed a lot of resolved data as compared to NAS and PCA. Thus, the NAS-PCA technique is a combination of NAS and PCA methods which is advantageous to obtain the information from overlapping results.
机译:在这项研究中,描述了同时测定组合药物片剂中氢氯噻嗪(HCTZ),盐酸肼苯哒嗪(H.HCl)和利血平(RES)的新型可行的紫外可见分光光度法和多元分光光度法。甲醇用作分析溶剂,整个UV区在200–400 nm范围内扫描。通过使用多种方法(例如净分析物信号方法(NAS),主成分分析(PCA)和净分析物信号主要成分分析(NAS-PCA))获得分辨率,该方法适用于混合物的UV光谱。比较了从所有三种方法获得的结果。与NAS和PCA相比,NAS-PCA显示了很多已解析的数据。因此,NAS-PCA技术是NAS和PCA方法的组合,有利于从重叠结果中获取信息。

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