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首页> 外文期刊>Asian journal of research in chemistry >Spectrophotometric estimation of Nebivolol hydrochloride and HPTLC method for simultaneous determination of Nebivolol hydrochloride and Hydrochlorothiazide in bulk drug and in pharmaceutical formulation
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Spectrophotometric estimation of Nebivolol hydrochloride and HPTLC method for simultaneous determination of Nebivolol hydrochloride and Hydrochlorothiazide in bulk drug and in pharmaceutical formulation

机译：盐酸奈必洛尔的分光光度估计和HPTLC法同时测定原料药和药物制剂中盐酸奈必洛尔和氢氯噻嗪

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摘要

A rapid assay procedure have been developed for the determination of Nebivolol hydrochloride based on application of oxidant to the spectrophotometry and high performance thin layer chromatography (HPTLC) have been developed for simultaneous determination of Nebivolol hydrochloride and Hydrochlorothiazide in a bulk drug and phamiaceutical formulation. In spectrophotometric method, Nebivolol Hydrochloride is treated with a known excess of cerium (TV) sulphate and the residual oxidant is determined by treating with a fixed amount of indigo carmine, and measuring the absorbance at 610 nm and Chromatographic separation was achieved on aluminum foil plates precoated with silica gel 60GF-254, with chloroform: toluene: methanol: ammonia (5:3:2:0.1, v/v/v/v) as mobile phase. Detection was performed densitometrically at 278 nm. The R_F of Nebivolol and Hydrochlorothiazide were 0.30 and 0.42, respectively. In spectrophotometry. Beer's law is obeyed over concentration range of 2- 10 μg/mL. The results of the proposed procedures were validated statistically. The proposed methods were simple, accurate, and rapid and can therefore be used for routine analysis of both drugs in quality control laboratories.
机译：基于氧化剂在分光光度法上的应用，已经开发了一种快速测定盐酸奈必洛尔的测定方法，同时还开发了高效薄层色谱（HPTLC）用于同时测定散装药物和药物制剂中的盐酸奈必洛尔和氢氯噻嗪。在分光光度法中，奈比洛尔盐酸盐用已知过量的硫酸铈（TV）处理，残留的氧化剂通过用固定量的靛蓝胭脂红处理，并测量610 nm的吸光度，并在铝箔板上完成色谱分离预涂硅胶60GF-254，并用氯仿：甲苯：甲醇：氨水（5：3：2：0.1，v / v / v / v）作为流动相。在278nm处进行光密度检测。奈比洛尔和氢氯噻嗪的R_F分别为0.30和0.42。在分光光度法中。在2-10μg/ mL的浓度范围内遵守比尔定律。拟议程序的结果经过统计学验证。所提出的方法简单，准确，快速，因此可用于质量控制实验室中两种药物的常规分析。

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