• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Standards in Genomic Sciences >The complete genome sequence of Eubacterium limosum SA11 a metabolically versatile rumen acetogen
【2h】

The complete genome sequence of Eubacterium limosum SA11 a metabolically versatile rumen acetogen

机译：代谢通用的瘤胃产醋杆菌Eubacterium limosum SA11的完整基因组序列

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acetogens are a specialized group of anaerobic bacteria able to produce acetate from CO2 and H2 via the Wood–Ljungdahl pathway. In some gut environments acetogens can compete with methanogens for H2, and as a result rumen acetogens are of interest in the development of microbial approaches for methane mitigation. The acetogen Eubacterium limosum SA11 was isolated from the rumen of a New Zealand sheep and its genome has been sequenced to examine its potential application in methane mitigation strategies, particularly in situations where hydrogenotrophic methanogens are inhibited resulting in increased H2 levels in the rumen. The 4.15 Mb chromosome of SA11 has an average G + C content of 47 %, and encodes 3805 protein-coding genes. There is a single prophage inserted in the chromosome, and several other gene clusters appear to have been acquired by horizontal transfer. These include genes for cell wall glycopolymers, a type VII secretion system, cell surface proteins and chemotaxis. SA11 is able to use a variety of organic substrates in addition to H2/CO2, with acetate and butyrate as the principal fermentation end-products, and genes involved in these metabolic pathways have been identified. An unusual feature is the presence of 39 genes encoding trimethylamine methyltransferase family proteins, more than any other bacterial genome. Overall, SA11 is a metabolically versatile organism, but its ability to grow on such a wide range of substrates suggests it may not be a suitable candidate to take the place of hydrogen-utilizing methanogens in the rumen.Electronic supplementary materialThe online version of this article (doi:10.1186/s40793-016-0147-9) contains supplementary material, which is available to authorized users.
机译：产乙酸菌是一组专门的厌氧细菌，它们能够通过Wood-Ljungdahl途径从CO2和H2中产生乙酸盐。在某些肠道环境中，产乙酸菌可以与产甲烷菌竞争H2，因此，瘤胃产乙酸菌在开发用于缓解甲烷的微生物方法中引起了人们的兴趣。从新西兰绵羊的瘤胃中分离了产乙酸优生细菌SA11，并对其基因组进行了测序，以检查其在甲烷减缓策略中的潜在应用，特别是在氢营养型产甲烷菌被抑制导致瘤胃中H2水平升高的情况下。 SA11的4.15 Mb染色体平均G + C含量为47％，编码3805个蛋白质编码基因。在染色体中插入了一个原噬菌体，其他几个基因簇似乎是通过水平转移获得的。这些包括细胞壁糖聚合物的基因，VII型分泌系统，细胞表面蛋白和趋化性。 SA11能够使用除H2 / CO2之外的各种有机底物，其中乙酸盐和丁酸盐是主要的发酵终产物，并且已经确定了与这些代谢途径有关的基因。一个不寻常的特征是存在编码三甲胺甲基转移酶家族蛋白的39个基因，比任何其他细菌基因组都多。总的来说，SA11是一种具有代谢功能的生物，但其在如此广泛的底物上生长的能力表明，它可能不是替代瘤胃中利用氢的产甲烷菌的合适人选。 （doi：10.1186 / s40793-016-0147-9）包含补充材料，授权用户可以使用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号