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首页> 美国卫生研究院文献>Substance Abuse: Research and Treatment >A Comparison of Buprenorphine + Naloxone to Buprenorphine and Methadone in the Treatment of Opioid Dependence during Pregnancy: Maternal and Neonatal Outcomes
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A Comparison of Buprenorphine + Naloxone to Buprenorphine and Methadone in the Treatment of Opioid Dependence during Pregnancy: Maternal and Neonatal Outcomes

机译：丁丙诺啡+纳洛酮与丁丙诺啡和美沙酮在妊娠期间阿片类药物依赖性治疗中的比较：母婴结局

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Given that buprenorphine + naloxone is prescribed for opioid-dependent pregnant women, it is important to examine the extent to which it differs from buprenorphine alone, methadone, or methadone-assisted withdrawal on neonatal and maternal outcomes. Summary statistics on maternal and neonatal outcomes were collected from 7 previously published studies examining treatment for opioid-dependent pregnant women that represented a range of research methodologies. Outcomes from these studies were compared to the same outcomes for 10 women treated with the combined buprenorphine + naloxone product. There were no significant differences in maternal outcomes for buprenorphine + naloxone compared to buprenorphine, methadone, or methadone-assisted withdrawal. Preliminary findings suggest no significant adverse maternal or neonatal outcomes related to the use of buprenorphine + naloxone for the treatment of opioid dependence during pregnancy. However, further research should examine possible differences between buprenorphine + naloxone and buprenorphine alone or methadone in fetal physical development.
机译：鉴于对阿片类药物依赖性孕妇开具丁丙诺啡+纳洛酮的处方，重要的是要检查其在新生儿和产妇预后方面与单独使用丁丙诺啡，美沙酮或美沙酮辅助戒断的程度不同。母体和新生儿结局的摘要统计数据来自7项先前发表的研究，这些研究检查了阿片类药物依赖性孕妇的治疗方法，这些方法代表了多种研究方法。将这些研究的结果与使用丁丙诺啡+纳洛酮联合产品治疗的10名妇女的相同结果进行了比较。与丁丙诺啡，美沙酮或美沙酮辅助戒断相比，丁丙诺啡+纳洛酮的孕产妇结局无显着差异。初步研究结果表明，与丁丙诺啡+纳洛酮治疗妊娠期阿片类药物依赖性相关的母体或新生儿无明显不良后果。但是，进一步的研究应检查丁丙诺啡+纳洛酮与单独丁丙诺啡或美沙酮在胎儿身体发育中的可能差异。

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