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Variation of swimming speed enhances the chemotactic migration of Escherichia coli

机译：游泳速度的变化增强了大肠杆菌的趋化迁移

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Studies on chemotaxis of Escherichia coli have shown that modulation of tumble frequency causes a net drift up the gradient of attractants. Recently, it has been demonstrated that the bacteria is also capable of varying its runs speed in uniform concentration of attractant. In this study, we investigate the role of swimming speed on the chemotactic migration of bacteria. To this end, cells are exposed to gradients of a non-metabolizable analogue of glucose which are sensed via the Trg sensor. When exposed to a gradient, the cells modulate their tumble duration, which is accompanied with variation in swimming speed leading to drift velocities that are much higher than those achieved through the modulation of the tumble duration alone. We use an existing intra-cellular model developed for the Tar receptor and incorporate the variation of the swimming speed along with modulation of tumble frequency to predict drift velocities close to the measured values. The main implication of our study is that E. coli not only modulates the tumble frequency, but may also vary the swimming speed to affect chemotaxis and thereby efficiently sample its nutritionally rich environment.Electronic supplementary materialThe online version of this article (doi:10.1007/s11693-015-9174-x) contains supplementary material, which is available to authorized users.
机译：对大肠埃希氏菌趋化性的研究表明，滚转频率的调节会引起净向上漂移的引诱剂梯度。最近，已经证明细菌还能够在引诱剂的均匀浓度下改变其运行速度。在这项研究中，我们调查游泳速度对细菌趋化迁移的作用。为此，将细胞暴露于不可代谢的葡萄糖类似物的梯度中，该梯度是通过Trg传感器检测到的。当暴露于梯度时，细胞调节其翻转持续时间，伴随着游泳速度的变化，导致漂移速度远高于仅通过调节翻转持续时间所实现的漂移速度。我们使用针对Tar受体开发的现有细胞内模型，并结合游泳速度的变化以及滚降频率的调制来预测接近测量值的漂移速度。我们研究的主要意义在于大肠杆菌不仅可以调节滚转频率，还可以改变游泳速度以影响趋化性，从而有效地采样其营养丰富的环境。电子补充材料本文的在线版本（doi：10.1007 / s11693-015-9174-x）包含补充材料，授权用户可以使用。

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