• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Theranostics >Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors
【2h】

Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors

机译：具有双临界溶液温度行为的热和pH双响应聚合物胶束用于光声成像引导的协同化学光热疗法可治疗皮下和转移性乳腺肿瘤

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chemo-photothermal therapy shows great potential for inhibiting tumor growth. However, achieving maximal chemo-photothermal synergistic efficacy is challenging because of the low efficiency of controllable chemo-drug release in response to external or internal triggers. Thus, a nano-delivery system that could effectively achieve photothermal therapy and dual stimuli-responsive (heat and pH) drug release to inhibit both primary breast tumor growth and metastases is required.>Methods: Herein, a thermo- and pH-responsive polymer (mPEG-PAAV) with an upper critical solution temperature (UCST) was synthesized to fabricate a DOX- and IR780-loaded micellar system. After systematic studies of the photothermal performance and controllable drug release of mPEG-PAAV micelles/IR780+DOX under NIR irradiation at different pH values, their chemo-photothermal synergetic therapy efficacies were also estimated both in in vitro and in vivo.>Results: Because of the photothermal conversion of mPEG-PAAV micelle/IR780+DOX (~200 nm, 3.82 mV), high local temperature could be induced at the tumor site under NIR laser irradiation. This hyperthermia not only produced an enhanced tumor necrosis, but also broke down the micelles under the decreased pH environment, resulting in rapid DOX release and enhanced intracellular drug accumulation after NIR laser irradiation. In addition, photoacoustic imaging (PAI) of mPEG-PAAV/IR780+DOX micelle was adopted to monitor the morphology and micro-vascular distribution of the tumor tissue, which could also guide the chemo-photothermal therapy. Most importantly, the systemic administration of mPEG-PAAV micelles/IR780+DOX combined with NIR laser irradiation could simultaneously eliminate the 4T1 breast tumor and thoroughly suppress lung metastasis without any obvious adverse effects.>Conclusion: Herein, a pH- and thermo-dual responsive UCST micelle system was developed for delivering IR780 and DOX, which could achieve NIR laser-controlled drug release and PA imaging guidance for chemo-photothermal synergistic therapy of both primary breast tumors and their metastases.
机译：化学光热疗法显示出抑制肿瘤生长的巨大潜力。然而，由于对外部或内部触发因素的可控化学药物释放效率低，因此实现最大的化学-光热协同功效具有挑战性。因此，需要一种能够有效实现光热疗法和双重刺激反应（热和pH值）药物释放以抑制原发性乳腺肿瘤生长和转移的纳米传递系统。>方法： -合成具有最高临界溶液温度（UCST）的pH响应聚合物（mPEG-PAAV），以制造装载有DOX和IR780的胶束系统。系统研究了在不同pH值下NIR照射下mPEG-PAAV胶束/ IR780 + DOX的光热性能和可控药物释放，还评估了它们在体外和体内的化学-光热协同治疗效果。>结果：：由于mPEG-PAAV胶束/ IR780 + DOX的光热转化（〜200 nm，3.82 mV），在NIR激光照射下可能在肿瘤部位诱发较高的局部温度。这种高热不仅产生增强的肿瘤坏死，而且在pH降低的环境下分解了胶束，导致DOX迅速释放并在NIR激光照射后增强了细胞内药物的积累。此外，采用mPEG-PAAV / IR780 + DOX胶束的光声成像（PAI）监测肿瘤组织的形态和微血管分布，这也可以指导化学光热疗法的发展。最重要的是，mPEG-PAAV胶束/ IR780 + DOX与NIR激光照射的全身给药可以同时消除4T1乳腺肿瘤并彻底抑制肺转移，而没有任何明显的不良影响。>结论：开发了pH和热双反应UCST胶束系统，用于递送IR780和DOX，该系统可实现NIR激光控制的药物释放和PA成像指导，用于化学光热协同治疗原发性乳腺肿瘤及其转移。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号