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首页> 美国卫生研究院文献>Turkish Journal of Biology >Analyzing formation of silver nanoparticles from the filamentous fungus Fusarium oxysporum and their antimicrobial activity
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Analyzing formation of silver nanoparticles from the filamentous fungus Fusarium oxysporum and their antimicrobial activity

机译：分析丝状真菌尖孢镰刀菌银纳米颗粒的形成及其抗菌活性

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In recent years much attention has been paid to the biosynthesis of silver nanoparticles (AgNPs) and their important medical applications. The current study employs Fusarium oxysporum for the formation of silver nanoparticles and examines the antimicrobial activity of the particles against some multidrug-resistant (MDR) microbes. Silver nitrate was transformed into silver oxide, forming well-dispersed nanoparticles, by the action of F. oxysporum metabolically. The size of the nanoparticles ranged from 21.3 to 37.3 nm, and UV-spectroscopy showed a peak at 408-411 nm. Moreover, SEM, TEM, and AFM results revealed spherical and oval shapes and showed no sign of aggregation. Furthermore, the FT-IR histogram detected amide I and amide II, which are responsible for the stability of AgNPs in the aqueous solution. The AgNPs halted the growth of MDR bacteria, including some members of Enterobacteriaceae and Staphylococcus species at a concentration of 50% (v/v). The AgNPs also have the ability to inhibit pathogenic yeasts Candida albicans and Candida krusei. The AgNPs displayed antigrowth activity against MDR microbes, suggesting that they might be potential alternatives to antibiotics. However, additional studies may be necessary to substantiate the fact that the benefits of using nanoparticles outweigh the potential risks.
机译：近年来，银纳米颗粒（AgNPs）的生物合成及其重要的医学应用引起了广泛关注。当前的研究采用尖孢镰刀菌（Fusarium oxysporum）形成银纳米颗粒，并研究了该颗粒对某些耐多药（MDR）微生物的抗菌活性。硝酸银在镰刀菌的代谢作用下转变为氧化银，形成分散良好的纳米颗粒。纳米粒子的尺寸范围为21.3至37.3 nm，紫外光谱显示在408-411 nm处有一个峰。此外，SEM，TEM和AFM结果显示球形和椭圆形，并且没有聚集迹象。此外，FT-IR直方图检测到酰胺I和酰胺II，它们负责水溶液中AgNP的稳定性。 AgNPs以50％（v / v）的浓度阻止了MDR细菌的生长，包括肠杆菌科和葡萄球菌的某些成员。 AgNP还具有抑制致病酵母白色念珠菌和克鲁斯念珠菌的能力。 AgNPs具有抗MDR微生物的抗生长活性，表明它们可能是抗生素的潜在替代品。但是，可能需要进行更多的研究来证实使用纳米颗粒的好处大于潜在风险这一事实。

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