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Current Concepts of Viral Hepatitis and A Peek into the Future

机译:当前病毒性肝炎的概念及未来展望

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摘要

New information has prompted revision of the conceptual framework for considering the epidemiology and virology of viral hepatitis. The means are now at hand to identify infections due to either Hepatitis A or B, as well as to implicate other etiologic agents in hepatitis. Immunologic evidence of variation in the antigens associated with Hepatitis B, and possibly in Hepatitis A, may explain some well known epidemiologic phenomena and has important implications in immune serum globulin prophylaxis. The ambiguous relationship of antigenemia and viremia in Hepatitis B is explored in relation to the hepatitis hazard of blood products, to trials of immune serum globulin, and to the potential role of the carrier-health worker in hepatitis transmission. The emerging concept of non-parenteral transmission of Hepatitis B is reviewed and future developments in the production of hepatitis vaccines and in experimental viral hepatitis in non-human primates is briefly discussed.
机译:新信息促使修订了考虑病毒性肝炎流行病学和病毒学的概念框架。现在可以使用这种方法来识别由甲型或乙型肝炎引起的感染,以及暗示肝炎中的其他病原体。乙型肝炎相关抗原以及甲型肝炎相关抗原变异的免疫学证据可能解释了一些众所周知的流行病学现象,并且对免疫血清球蛋白的预防具有重要意义。探讨了乙型肝炎中抗原血症和病毒血症之间的模棱两可的关系,涉及血液制品对肝炎的危害,对免疫血清球蛋白的试验以及携带卫生工作者在肝炎传播中的潜在作用。本文回顾了新兴的非乙型肝炎非胃肠外传播概念,并简要讨论了在非人类灵长类动物中生产肝炎疫苗和实验性病毒性肝炎的未来发展。

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