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首页> 美国卫生研究院文献>Upsala Journal of Medical Sciences >Human neutrophil lipocalin (HNL) as a biomarker of acute infections
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Human neutrophil lipocalin (HNL) as a biomarker of acute infections

机译：人类嗜中性白血球脂蛋白（HNL）作为急性感染的生物标志物

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摘要

The early and accurate discrimination between bacterial and viral causes of acute infections is the key to a better use of antibiotics and will help slow down the fast-growing resistance to commonly used antibiotics. This discrimination is in the vast majority of cases possible to achieve by blood assay of the biomarker human neutrophil lipocalin (HNL), which we showed to be uniquely increased in patients suffering from bacterial infections. In serum, sensitivities and specificities of >90% are achieved in both adults and children. In order to eliminate the need to produce serum, a whole-blood assay with an assay time of <10 min was developed in which blood neutrophils are activated to release HNL. The diagnostic accuracy of this assay also showed sensitivities and specificities of >90% in most infectious diseases and was clearly superior to contemporary assays such as blood neutrophil counts, C-reactive protein, procalcitonin, and expression of CD64 on blood neutrophils. This format lends itself to the development of a point-of-care HNL assay and will be a major step forward to accomplish the goal of accurately diagnosing patients with symptoms of acute infections within 10 min at the emergency room or at the doctor’s office.
机译：对细菌和病毒引起的急性感染的早期，准确的区分是更好地使用抗生素的关键，并将有助于减缓对常用抗生素的快速增长的耐药性。在大多数情况下，通过血液标志物人类嗜中性白血球脂蛋白（HNL）的血液检测可以实现这种区分，我们发现在细菌感染的患者中这种独特增加。在血清中，成人和儿童的敏感性和特异性均> 90％。为了消除产生血清的需要，开发了一种测定时间小于10分钟的全血测定法，其中激活了血液中性粒细胞以释放HNL。该测定法的诊断准确性在大多数传染性疾病中也显示出> 90％的敏感性和特异性，并且明显优于当代测定法，例如血液中性粒细胞计数，C反应蛋白，降钙素和血液中性粒细胞上CD64的表达。这种格式有助于现场即时HNL检测的发展，它将是朝着在急诊室或医生办公室10分钟内准确诊断出急性感染症状的目标迈出的重要一步。

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