Short-term effect of the HMG-CoA reductase inhibitor rosuvastatin on erythrocyte nitric oxide synthase activity

机译：HMG-CoA还原酶抑制剂瑞舒伐他汀对红细胞一氧化氮合酶活性的短期影响

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Prevention and treatment of cardiovascular disorders by HMG-CoA reductase inhibitors (or statins), beyond their lipid-lowering properties, have been demonstrated including activation of the endothelial nitric oxide synthase (eNOS). Beside endothelial cells, red blood cells (RBCs) possess NOS and produce nitric oxide (NO), which contributes to RBC deformability. The present study tested the capacity of statins to activate NOS in RBCs and subsequently to modulate RBC deformability in vitro. Blood samples of healthy young volunteers were incubated with or without rosuvastatin. Afterwards RBC-NOS activity and RBC deformability were determined. Rosuvastatin incubation significantly increased NOS phosphorylation, NOS dependent NO-formation, and RBC deformability. The NOS inhibitor NG- monomethyl-L-arginine reversed the stimulatory effect of rosuvastatin on RBC-NOS activity. This NO dependent effect of rosuvastatin might have an important influence on microcirculation and may offer new perspectives for the therapeutic use of statins.

机译：已经证明，通过HMG-CoA还原酶抑制剂（或他汀类药物）可预防和治疗心血管疾病，除了具有降低脂质的特性外，还包括激活内皮一氧化氮合酶（eNOS）。除内皮细胞外，红细胞（RBC）具有NOS并产生一氧化氮（NO），这有助于RBC变形。本研究测试了他汀类药物激活红细胞中NOS并随后在体外调节RBC变形能力的能力。将健康的年轻志愿者的血液样本与或不与瑞舒伐他汀一起孵育。然后测定RBC-NOS活性和RBC可变形性。瑞舒伐他汀孵育显着增加了NOS磷酸化，NOS依赖性NO的形成和RBC的可变形性。 NOS抑制剂NG-单甲基-L-精氨酸逆转了瑞舒伐他汀对RBC-NOS活性的刺激作用。瑞舒伐他汀的这种NO依赖性效应可能对微循环产生重要影响，并可能为他汀类药物的治疗用途提供新的见解。

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期刊名称 Vascular Health and Risk Management
作者
Barbara Ludolph; Wilhelm Bloch; Malte Kelm; Rainer Schulz; Petra Kleinbongard;
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作者单位

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年(卷),期 2007(3),6
年度 2007
页码 1069–1073
总页数 6
原文格式 PDF
正文语种
中图分类病理学;
关键词
red blood cell nitric oxide synthase red blood cell deformability statin;

机译：红细胞;一氧化氮合酶;红细胞变形性;他汀类;

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专利

1. HMG-CoA还原酶抑制剂对胃癌细胞增殖的影响 [J] . 丁小云, 李定国, 陆汉明, 癌症（英文版） . 2001,第005期
2. Short-term effect of the HMG-CoA reductase inhibitor rosuvastatin on erythrocyte nitric oxide synthase activity [J] . Barbara Ludolph, Wilhelm Bloch, Malte Kelm, Vascular Health and Risk Management . 2007,第6期

机译：HMG-CoA还原酶抑制剂瑞舒伐他汀对红细胞一氧化氮合酶活性的短期影响
3. Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. [J] . Laufs U, Gertz K, Dirnagl U, Brain research . 2002,第1a2期

机译：瑞舒伐他汀是一种新型的HMG-CoA还原酶抑制剂，可上调内皮一氧化氮合酶并保护小鼠免于缺血性中风。
4. HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages. [J] . Huang KC, Chen CW, Chen JC, Journal of biomedical science. . 2003,第4期

机译：HMG-CoA还原酶抑制剂抑制巨噬细胞中可诱导的一氧化氮合酶基因表达。
5. Pulmonary Arterial Pressure and Electrocardiograms in Broiler Chickens Infused Intravenously with L-NAME, an Inhibitor of Nitric Oxide Synthase, or Sodium Nitroprusside (SNP), a Nitric Oxide Donor [C] . Wei-Dong Sun, Xiao-Long Wang, Jin-Yong Wang, International Conference on Avian Nutritional and Metabolic Disorders; 20060414-17; Nanjing(CN) . 2006

机译：静脉输注一氧化氮合酶抑制剂L-NAME或一氧化氮供体硝普钠（SNP）的肉鸡的肺动脉压和心电图
6. NG-nitro-L-arginine-containing peptidomimetics as selective neuronal nitric oxide synthase inhibitors. Structure-based design, synthesis, and biological evaluation and approaches toward enhanced CNS activity. [D] . Seo, Jiwon. 2006

机译：含NG-硝基-L-精氨酸的拟肽作为选择性神经元一氧化氮合酶抑制剂。基于结构的设计，合成和生物学评估以及增强CNS活性的方法。
7. HMG-CoA Reductase Inhibitor Improves Endothelial Dysfunction in Spontaneous Hypertensive Rats Via Down-regulation of Caveolin-1 and Activation of Endothelial Nitric Oxide Synthase [O] . Jung-Won Suh, Dong-Ju Choi, Hyuk-Jae Chang, 2010

机译：HMG-CoA还原酶抑制剂通过下调Caveolin-1和激活内皮型一氧化氮合酶来改善自发性高血压大鼠的内皮功能障碍
8. HMG-CoA Reductase Inhibitor Improves Endothelial Dysfunction in Spontaneous Hypertensive Rats Via Down-regulation of Caveolin-1 and Activation of Endothelial Nitric Oxide Synthase [O] . Suh, Jung-Won, Choi, Dong-Ju, Chang, Hyuk-Jae, 2010

机译：HMG-CoA还原酶抑制剂通过下调Caveolin-1和激活内皮型一氧化氮合酶来改善自发性高血压大鼠的内皮功能障碍
9. Geldanamycin Inhibits Hemorrhage-Induced Increases in Caspase-3 Activity: Role of Inducible Nitric Oxide Synthase. [R] . Kiang, J. G., Bowman, P. D., Lu, X., 2007

机译：格尔德霉素抑制出血诱导的Caspase-3活性增加：诱导型一氧化氮合酶的作用。

Short-term effect of the HMG-CoA reductase inhibitor rosuvastatin on erythrocyte nitric oxide synthase activity

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