• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Virology Journal >Neutralizing antibody response in the patients with hand foot and mouth disease to enterovirus 71 and its clinical implications
【2h】

Neutralizing antibody response in the patients with hand foot and mouth disease to enterovirus 71 and its clinical implications

机译：手足口病患者对肠道病毒71的中和抗体反应及其临床意义

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Enterovirus 71 (EV71) has emerged as a significant pathogen causing large outbreaks in China for the past 3 years. Developing an EV71 vaccine is urgently needed to stop the spread of the disease; however, the adaptive immune response of humans to EV71 infection remains unclear. We examined the neutralizing antibody titers in HFMD patients and compared them to those of asymptomatic healthy children and young adults. We found that 80% of HFMD patients became positive for neutralizing antibodies against EV71 (GMT = 24.3) one day after the onset of illness. The antibody titers in the patients peaked two days (GMT = 79.5) after the illness appeared and were comparable to the level of adults (GMT = 45.2). Noticeably, the antibody response was not correlated with disease severity, suggesting that cellular immune response, besides neutralizing antibodies, could play critical role in controlling the outcome of EV71 infection in humans.
机译：在过去的三年中，肠道病毒71（EV71）已成为导致中国大规模暴发的重要病原体。迫切需要开发一种EV71疫苗来阻止疾病的传播。然而，人类对EV71感染的适应性免疫反应仍不清楚。我们检查了手足口病患者的中和抗体滴度，并将其与无症状健康儿童和年轻人的滴度进行了比较。我们发现，发病后一天，有80％的HFMD患者中和抗EV71抗体（GMT = 24.3）呈阳性。患病后两天（GMT = 79.5），患者的抗体效价达到峰值，与成人水平相当（GMT = 45.2）。值得注意的是，抗体反应与疾病严重程度无关，这表明除中和抗体外，细胞免疫反应在控制人类EV71感染的结果中可能起关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号