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首页> 外文会议>International conference on intelligent computing >Analyzing the Genomes of Coxsackievirus A16 and Enterovirus 71 in Relation to Hand, Foot and Mouth Disease(HFMD) Using Apriori Algorithm, Decision Tree and Support Vector Machine (SVM)
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Analyzing the Genomes of Coxsackievirus A16 and Enterovirus 71 in Relation to Hand, Foot and Mouth Disease(HFMD) Using Apriori Algorithm, Decision Tree and Support Vector Machine (SVM)

机译：使用Apriori算法，决策树和支持向量机（SVM）分析与手足口病（HFMD）相关的柯萨奇病毒A16和肠道病毒71的基因组

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摘要

Hand, foot and mouth disease (HFMD), caused by highly infectious intestinal viruses of either coxsackievirus A16 (CVA16) or enterovirus 71 (EV71), is a common children syndrome featured by mild fever, spots and bumps that blister the skin of hands, oral cavity in mouth, feet and sometimes to the extent of buttocks and genitalia. Though CVA16 and EV71 both cause the HFMD, the intensity of each symptom is obviously different. Normal cases are HFMD by CVA16, which are typically characterized by mild symptoms usually treated in 6-8 days. Conversely, HFMD by EV71 results severe neural disorders and various influenza complications that even cause death. Currently, no vaccine is available to protect individuals from infection by the viruses that cause HFMD. In order to investigate why these two viruses have too much differences in degree of symptoms and compare the inner relationships to the medical effects, we analyzed the genomes of CVA16 and EV71 by using apriori algorithm, decision tree and support vector machine (SVM). Therefore, by comparing the genomes of each virus, we found out better results for analyzing the relationship between the two and state the potential of developing medical remedy in DNA point of view.
机译：手足口病（HFMD）是由柯萨奇病毒A16（CVA16）或肠病毒71（EV71）的高传染性肠道病毒引起的，是一种常见的儿童综合症，其特征是轻度发烧，斑点和颠簸，使手部皮肤发红，口腔在口，脚上有时到臀部和生殖器的程度。尽管CVA16和EV71均引起手足口病，但每种症状的强度明显不同。正常病例是CVA16引起的手足口病，通常表现为轻度症状，通常在6-8天内得到治疗。相反，EV71引起的手足口病会导致严重的神经疾病和各种流感并发症，甚至导致死亡。当前，没有可用的疫苗来保护个体免受引起手足口病的病毒的感染。为了调查为什么这两种病毒的症状程度差异太大并比较其内在联系与医疗效果，我们使用先验算法，决策树和支持向量机（SVM）分析了CVA16和EV71的基因组。因此，通过比较每种病毒的基因组，我们发现了更好的结果，可用于分析两者之间的关系，并从DNA的角度阐明了发展医学疗法的潜力。

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