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首页> 外文期刊>Archives of Virology >Molecular characterization and complete genome analysis of human enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Thailand during 2008-2011
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Molecular characterization and complete genome analysis of human enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Thailand during 2008-2011

机译：2008-2011年泰国手足口病患儿的人类肠道病毒71和柯萨奇病毒A16的分子表征和完整基因组分析

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摘要

Hand, foot and mouth disease (HFMD) has mostly been caused by enterovirus 71 (EV71) and coxsackievirus A16 (CA16). CA 16 was the most common cause of HFMD in 2010. EV71 had a high prevalence in 2008-2009 and has been identified with a higher frequency since 2011. Nearly complete genome sequences of three EV71 strains (2008-2009 strains) and two CA16 strains (2010 strains) obtained from outbreaks in Thailand in 2008 to 2010 were characterized. Based on a phylogenetic tree of the complete VP1 region, three EV71 strains grouped into the B5, C1 and C4 genotypes, and two CA16 strains grouped into the C genotype. Based on sequence analysis, nucleotide changes were found to cluster in the internal ribosome entry site (IRES) element of the 5′-untranslated region (5′-UTR). Amino acid differences identified in all strains were located in the non-structural protein. These data also provide the molecular epidemiology of EV71 and CA16 outbreaks in Thailand.
机译：手足口病（HFMD）主要由肠道病毒71（EV71）和柯萨奇病毒A16（CA16）引起。 CA 16是2010年引起手足口病的最常见原因。EV71在2008-2009年患病率很高，并且自2011年以来被发现的频率更高。三个EV71菌株（2008-2009菌株）和两个CA16菌株的基因组序列接近完整从2008年至2010年泰国暴发中获得的（2010株）进行了表征。根据完整VP1区域的系统树，将三个EV71菌株分为B5，C1和C4基因型，将两个CA16菌株归为C基因型。基于序列分析，发现核苷酸变化聚集在5'非翻译区（5'-UTR）的内部核糖体进入位点（IRES）元件中。在所有菌株中鉴定出的氨基酸差异位于非结构蛋白中。这些数据还提供了泰国EV71和CA16暴发的分子流行病学。

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