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Drug resistance evolution in patients with human immunodeficiency virus-1 under long-term antiretroviral treatment-failure in Yunnan Province China

机译：云南省长期抗逆转录病毒治疗失败的人类免疫缺陷病毒-1患者的耐药性演变

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BackgroundUnderstanding the prevalence and evolution of HIV-1 drug resistance (DR) and associated mutation patterns is critical to implementing free antiretroviral therapy in Yunnan, the first antiretroviral treatment location in China. Here We provide a basis for understanding the occurrence and development of HIV-1 resistance in Yunnan and a theoretical foundational for strategy to delay HIV-1 drug resistance and achieve successful individualized treatment.

机译：背景技术了解HIV-1耐药性（DR）的流行和演变以及相关的突变模式对于在云南实施免费的抗逆转录病毒疗法至关重要，这是中国第一个抗逆转录病毒治疗地点。在这里，我们为了解云南省HIV-1耐药性的发生和发展提供了基础，并且为延迟HIV-1耐药性和成功实现个体化治疗的策略提供了理论基础。

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期刊名称 Virology Journal
作者
Jianjian Li; Yawen Xu; Jiafa Liu; Bihui Yang; Cuixian Yang; Mi Zhang; Xingqi Dong;
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作者单位

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年(卷),期 2019(16),-1
年度 2019
页码 5
总页数 10
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
HIV-1 AIDS Antiretroviral therapeutic failure Genotyping drug resistance Evolution;

机译：HIV-1;艾滋病;抗逆转录病毒治疗失败;基因分型耐药;进化;

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专利

1. Drug resistance evolution in patients with human immunodeficiency virus-1 under long-term antiretroviral treatment-failure in Yunnan Province, China [J] . Jianjian Li, Yawen Xu, Jiafa Liu, Virology Journal . 2019,第1期

机译：云南省长期抗逆转录病毒治疗失败的人类免疫缺陷病毒-1患者的耐药性演变
2. Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China. [J] . TuYQ, WangMJ, YaoJ, Transfusion: The Journal of the American Association of Blood Banks . 2009,第9期

机译：中国云南志愿献血者中人类免疫缺陷病毒-1基因型耐药性。
3. Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid [J] . Ignacio Pérez-Valero, Jesús Mingorance, José I. Bernardino, Open Forum Infectious Diseases . 2016,第1期

机译：长期控制人类免疫缺陷病毒-1复制，尽管对当前的抗逆转录病毒疗法有广泛的抵抗：原病毒脱氧核糖核酸中抗性突变的克隆分析
4. G-Quadruplexes in the Human Immunodeficiency Virus-1 and Herpes Simplex Virus-1: New Targets for Antiviral Activity by Small Molecules [C] . Rosalba Perrone, Sara Artusi, Elena Butovskaya International Conference on Biomedical Engineering in Vietnam . 2015

机译：人类免疫缺陷病毒-1中的G-Quadruplees和单纯疱疹病毒-1：小分子的抗病毒活动的新靶标
5. Viral Load Tests among People Living with Human Immunodeficiency Virus on Antiretroviral Therapy in Wenshan Prefecture, Yunnan Province of China [D] . Xu, Youran . 2019

机译：云南省云南省抗逆转录病毒治疗抗逆转录病毒治疗人类免疫缺陷病毒的病毒载荷试验
6. Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid [O] . Natalia Stella-Ascariz, Rocio Montejano, María Martin-Vicente, 2016

机译：长期控制人类免疫缺陷病毒-1复制尽管对当前的抗逆转录病毒疗法有广泛的抵抗：原病毒脱氧核糖核酸的抗性突变的克隆分析
7. Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid [O] . Natalia Stella-Ascariz, Rocio Montejano, María Martin-Vicente, 2016

机译：尽管对目前的抗逆转录病毒方案进行了广泛的抗性，但是对人免疫缺陷病毒-1复制的长期控制：脱氧核糖核酸中抗性突变的克隆分析
8. Low Prevalence of Human Immunodeficiency Virus-1 (HIV-1), HIV-2, and Human T CellLymphotropic Virus-1 Infection in Somalia [R] . Scott, D. A., Corwin, A. L., Constantine, N. T., 1991

机译：索马里人类免疫缺陷病毒-1（HIV-1），HIV-2和人类T细胞淋巴细胞病毒-1感染的低患病率

Drug resistance evolution in patients with human immunodeficiency virus-1 under long-term antiretroviral treatment-failure in Yunnan Province China

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