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A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile

机译：智利与人类汉坦病毒病例相关的小哺乳动物的19年分析

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Small mammals present in areas where hantavirus cardiopulmonary syndrome (HCPS) cases had occurred in central and southern Chile were captured and analyzed to evaluate the abundance of rodents and seroprevalence rates of antibodies to Andes orthohantavirus (ANDV). Sampling areas ranged from the Coquimbo to Aysén regions (30–45° S approx.) regions. Ninety-two sites in peridomestic and countryside areas were evaluated in 19 years of sampling. An antibody against ANDV was detected by strip immunoassay in 58 of 1847 specimens captured using Sherman traps. Of the eleven species of rodents sampled, Abrothrix olivacea, Oligoryzomys longicaudatus and Abrothrix hirta were the most frequently trapped. O. longicaudatus had the highest seropositivity rate, and by logistic regression analysis, O. longicaudatus of at least 60 g had 80% or higher probability to be seropositive. Sex, age and wounds were significantly related to seropositivity only for O. longicaudatus. Across administrative regions, the highest seropositivity was found in the El Maule region (34.8–36.2° S), and the highest number of HCPS cases was registered in the Aysén region. Our results highlight the importance of long term and geographically extended studies, particularly for highly fluctuating pathogens and their reservoirs, to understand the implications of the dynamics and transmission of zoonotic diseases in human populations.
机译：捕获并分析了智利中部和南部发生汉坦病毒性心肺综合征（HCPS）病例的地区的小型哺乳动物，并进行了评估，以评估啮齿动物的数量和安第斯正汉坦病毒（ANDV）抗体的血清阳性率。采样区域从科金博（Coquimbo）到艾森（Aysén）地区（约30–45°S）不等。在19年的采样中，评估了家畜和农村地区的92个站点。通过条带免疫测定法在使用谢尔曼捕集阱捕获的1847个样本中的58个样本中检测到抗ANDV的抗体。在所采样的11种啮齿动物中，最常被捕集的是Abrothrix olivacea，Oligoryzomys longicaudatus和Abrothrix hirta。 O. longicaudatus的血清阳性率最高，通过逻辑回归分析，至少60 g的O. longicaudatus的血清阳性率为80％或更高。性别，年龄和伤口仅与长曲霉血清阳性呈显着相关。在整个行政区域中，血清阳性率最高的地区是El Maule地区（34.8–36.2°S），而在Aysén地区则是最高的HCPS病例。我们的结果强调了长期的研究和在地理上扩展的研究的重要性，尤其是对于高度波动的病原体及其储藏库，以了解人畜共患疾病的动态和传播意义。

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