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Processes for producing fibrinogen and a progeny descent from a mammal embryo of a non-human mammal and a non-human mammal and a transgenic female non-human mammal
Processes for producing fibrinogen and a progeny descent from a mammal embryo of a non-human mammal and a non-human mammal and a transgenic female non-human mammal
Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding A alpha , B beta and gamma chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing fibrinogen expressed from the introduced DNA segments. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous fibrinogen polypeptide chains are also disclosed.
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