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首页> 美国卫生研究院文献>World Journal of Gastroenterology >Clinical and experimental study of effect of Raondix Salviae Militiorrhiza and other blood-activating and stasis-eliminating Chinese herbs on hemodynamics of portal hypertension
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Clinical and experimental study of effect of Raondix Salviae Militiorrhiza and other blood-activating and stasis-eliminating Chinese herbs on hemodynamics of portal hypertension

机译：丹参等活血化瘀中药对门脉高压血流动力学影响的临床和实验研究

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AIM: To study the effects of Radix Salviae Militiorrhiza (RSM), other blood-activating and stasis-eliminating Chinese herbs on hemodynamics of portal hypertension.METHODS: Portal pressure of cirrhotic dogs after chronic common bile duct ligation was measured directly; portal blood flow in patients with liver cirrhosis were detected by ultrasound Doppler.RESULTS: After administration of RSM and Radix Angelicae Sinensis (RAS) by intravenous infusion in cirrhosis dogs, the portal venous pressure (Ppv), wedge hepatic venous pressure (WHVP), hepatic venous pressure gradient (HVPG), were significantly decreased (P < 0.05-0.01), but the mean arterial pressure (MAP), and the heart rate (HR) remained unchanged. When nifedipine was used, Ppv, WHVP, MAP and HR were significantly decreased (P < 0.05), and the MVPG unchanged (P < 0.05). After administration of RSM, RSM + nifedipine and RSM + Hirudin + Nifedpin for 10-12 weeks, the diameter of portal vein (Dpv), spleen vein (Dsv), the portal venous flow (Qpv) and splenic venous flow (Qsv) in patients with hepatic cirrhosis were significantly lowered (P < 0.05-0.01), and the effect of RAS was weaker.CONCLUSION: The efficacy of decreasing Ppv by Chinese herbs－RSM, RAS, etc. as compared with nifedipine, demonstrated that the Chinese herbs were slower in action than that of nifedipine, but more long-lasting and without side effects. Hence, long-term administration of Chinese herbs, would be more beneficial.
机译：目的：研究丹参，其他活血化瘀中药对门脉高压血流动力学的影响。方法：直接测量慢性胆总管结扎后肝硬化犬的门静脉压；结果：肝硬化犬静脉输注RSM和当归（RAS）后，对肝硬化患者进行门静脉血流检测，门静脉压（Ppv），楔形肝静脉压（WHVP），肝静脉压梯度（HVPG）明显降低（P <0.05-0.01），但平均动脉压（MAP）和心率（HR）保持不变。使用硝苯地平时，Ppv，WHVP，MAP和HR显着降低（P <0.05），而MVPG不变（P <0.05）。给予RSM，RSM +硝苯地平和RSM + Hirudin + Nifedpin 10-12周后，门静脉直径（Dpv），脾静脉（Dsv），门静脉血流（Qpv）和脾静脉血流（Qsv）结论：中药（RSM，RAS等）与硝苯地平相比，降低肝硬化患者的Ppv效果明显，P <0.05-0.01，且RAS的作用较弱。比硝苯地平慢，但持续时间长，且无副作用。因此，长期服用中草药会更有益。

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