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首页> 美国卫生研究院文献>World Journal of Gastroenterology >A head to head comparison of oral vs intravenous omeprazole for patients with bleeding peptic ulcers with a clean base flat spots and adherent clots
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A head to head comparison of oral vs intravenous omeprazole for patients with bleeding peptic ulcers with a clean base flat spots and adherent clots

机译：口服奥美拉唑与口服奥美拉唑治疗消化性溃疡出血基础清洁斑点平坦且有血块粘附的患者的头对头比较

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AIM: To compare the effect of intravenous and oral omeprazole in patients with bleeding peptic ulcers without high-risk stigmata.METHODS: This randomized study included 211 patients [112 receiving iv omeprazole protocol (Group 1), 99 receiving po omeprazole 40 mg every 12 h (Group 2)] with a mean age of 52.7. In 144 patients the ulcers showed a clean base, and in 46 the ulcers showed flat spots and in 21 old adherent clots. The endpoints were re-bleeding, surgery, hospital stay, blood transfusion and death. After discharge, re-bleeding and death were re-evaluated within 30 d.RESULTS: The study groups were similar with respect to baseline characteristics. Re-bleeding was recorded in 5 patients of Group 1 and in 4 patients of Group 2 (P = 0.879). Three patients in Group 1 and 2 in Group 2 underwent surgery (P = 0.773). The mean length of hospital stay was 4.6 ± 1.6 d in Group 1 vs 4.5 ± 2.6 d in Group 2 (P = 0.710); the mean amounts of blood transfusion were 1.9 ± 1.1 units in Group 1 vs 2.1 ± 1.7 units in Group 2 (P = 0.350). Four patients, two in each group died (P = 0.981). After discharge, a new bleeding occurred in 2 patients of Group 1 and in 1 patient of Group 2, and one patient from Group 1 died.CONCLUSION: We demonstrate that the effect of oral omeprazole is as effective as intravenous therapy in terms of re-bleeding, surgery, transfusion requirements, hospitalization and mortality in patients with bleeding ulcers with low risk stigmata. These patients can be treated effectively with oral omeprazole.
机译：目的：为了比较静脉输注和口服奥美拉唑对出血性溃疡且无高危污名的患者的作用。方法：这项随机研究包括211例患者[112例接受静脉输注奥美拉唑方案（第1组），99例接受口服奥美拉唑40 mg每12 h（第2组）]，平均年龄为52.7。在144例患者中，溃疡表现出清洁的基底，在46例中，溃疡表现出平坦的斑点和21个旧的附着血块。终点为再次出血，手术，住院，输血和死亡。出院后，在30 d内对再次出血和死亡进行重新评估。结果：研究组的基线特征相似。在第1组的5例患者和第2组的4例患者中记录了再次出血（P = 0.879）。第1组和第2组的3例患者接受了手术（P = 0.773）。第一组的平均住院时间为4.6±1.6 d，而第二组的平均住院时间为4.5±2.6 d（P = 0.710）；第一组的平均输血量为1.9±1.1单位，而第二组的平均输血量为2.1±1.7单位（P = 0.350）。四名患者，每组两名死亡（P = 0.981）。出院后，第1组的2例患者和第2组的1例患者发生了新的出血，而第1组的1例患者死亡。结论：我们证明口服奥美拉唑的疗效与静脉内治疗一样有效低风险污名的出血性溃疡患者的出血，手术，输血要求，住院和死亡率。这些患者可以口服奥美拉唑有效治疗。

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