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Current status and future strategies of cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis

机译:细胞减灭术联合腹腔内高温化学疗法治疗腹膜癌的现状及未来对策

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摘要

This article is to offer a concise review on the use of cytoreductive surgery (CRS) plus intraperitoneal hyperthermic chemotherapy (IPHC) for the treatment of peritoneal carcinomatosis (PC). Traditionally, PC was treated with systemic chemotherapy alone with very poor response and a median survival of less than 6 mo. With the establishment of several phase II studies, a new trend has been developed toward the use of CRS plus IPHC as a standard method for treating selected patients with PC, in whom sufficient cytoreduction could be achieved. In spite of the need for more high quality phase III studies, there is now a consensus among many surgical oncology experts throughout the world about the use of this new treatment strategy as standard care for colorectal cancer patients with PC. This review summarizes the current status and possible progress in future.
机译:本文旨在简要介绍细胞减灭术(CRS)联合腹膜内高温化学疗法(IPHC)在治疗腹膜癌(PC)中的应用。传统上,PC仅通过全身化疗进行治疗,反应非常差,中位生存期不到6个月。随着几项II期研究的建立,使用CRS加IPHC作为治疗部分PC病患者的标准方法的新趋势已得到发展,在PC患者中可以实现足够的细胞减少作用。尽管需要进行更高质量的III期研究,但世界各地的许多外科肿瘤学专家对于将这种新的治疗策略用作PC结直肠癌患者的标准治疗方法已经达成共识。这篇综述总结了当前的现状以及未来可能的进展。

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